Trial reportThe journal of headache and pain2013
Topiramate modulates habituation in migraine: evidences from nociceptive responses elicited by laser evoked potentials.
Trial report in The journal of headache and pain, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 34 citations in OpenAlex.
- Effects of OnabotulintoxinA on Habituation of Laser Evoked Responses in Chronic Migraine.Toxins · 2016Trial
- Transcranial Direct Current Stimulation (tDCS) of the visual cortex: a proof-of-concept study based on interictal electrophysiological abnormalities in migraine.The journal of headache and pain · 2013Trial
- A Randomized, Double-Blind, Controlled Trial Protocol for Therapeutic Neuroscience Education in Chronic Migraine Patients: A Clinical-Neurophysiological Combined Study Design.Methods and protocols · 2025Article
- Neurophysiological investigations in a case of primary paroxysmal hemicrania-tic syndrome.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Article
- Interictal Dysfunctions of Attention, Vigilance, and Executive Functions in Migraine and Their Reversal by Preventive Treatment: A longitudinal Controlled Study.Annals of Indian Academy of Neurology · 2024Article
- Habituation to Pain in Patients with Chronic Pain: Clinical Implications and Future Directions.Journal of clinical medicine · 2023Review
- Somatosensory Gating Responses Are Associated with Prognosis in Patients with Migraine.Brain sciences · 2021Article
- Cortical pain processing in migraine.Journal of neural transmission (Vienna, Austria : 1996) · 2020Review
- A ketogenic diet normalizes interictal cortical but not subcortical responsivity in migraineurs.BMC neurology · 2019Article
- The search for pain biomarkers in the human brain.Brain : a journal of neurology · 2018Review
- Pain Perception and Migraine.Frontiers in neurology · 2018Review
- Habituation of laser-evoked potentials by migraine phase: a blinded longitudinal study.The journal of headache and pain · 2017Article
- Differences in central facilitation between episodic and chronic migraineurs in nociceptive-specific trigeminal pathways.The journal of headache and pain · 2016Article
- Alice in Wonderland Syndrome: A Clinical and Pathophysiological Review.BioMed research international · 2016Review
- Specificity of hemodynamic brain responses to painful stimuli: a functional near-infrared spectroscopy study.Scientific reports · 2015Article
- Habituation and sensitization in primary headaches.The journal of headache and pain · 2013Review
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLack of habituation during repetitive stimulation is the most consistent interictal abnormality of cortical information processing observed in migraine. Preventive migraine treatments might act by stabilizing cortical excitability level and thus the habituation to external stimuli.
methodsWe examined the effects of preventive treatment with topiramate on migraineur's habituation to nociceptive stimulation. Scalp potentials were evoked by Nd-YAP Laser stimulation of the hand dorsum and supraorbital region in 13 patients with migraine without aura (MO) and 15 healthy volunteers (HV). The exam was repeated in MO before and after treatment.
resultsWe observed a lack of habituation and lower initial amplitudes in MO compared to HV. These abnormalities reached statistical significance for N1 LEPs component, generated in the secondary somatosensory cortex (SII), but not for N2/P2 complex, generated in the insula and anterior cingulated cortex (ACC). Topiramate normalized the N1 habituation pattern in MO, with a significant correlation between clinical effects and normalization of neurophysiological responses.
conclusionsOur results indicate a modulating action of topiramate on cortical processing of sensorial stimuli, mainly regarding the sensory-discriminative component of pain, elaborated by SII, without a significant effect on the affective dimension of pain, in which the ACC has an important role.
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