Evidence map›Paper›PMID 23565989›Full record

ArticleThe journal of physical chemistry. B2013

Probing mercury(II)-DNA interactions by nanopore stochastic sensing.

Guihua Wang, Qitao Zhao, Xiaofeng Kang, Xiyun Guan

Abstract read
In one paragraph

Article in The journal of physical chemistry. B, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Review
  2. Review
  3. Probe-assisted detection of FeBiosensors & bioelectronics · 2024
    Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Nanopore Technology for the Application of Protein Detection.Nanomaterials (Basel, Switzerland) · 2021
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Guihua WangDepartment of Biological and Chemical Sciences, Illinois Institute of Technology, 3101 South Dearborn Street, Chicago, Illinois 60616, United States.
Qitao Zhao
Xiaofeng Kang
Xiyun Guan

Funding

99.99% Accuracy Direct DNA Sequencing via the Protein Nanopore MethodR01HG005095 · NHGRI · ELECTRONIC BIOSCIENCES, INC. · PI BARRALL, GEOFFREY · 2009 to 2012
$4.8M
NHGRI NIH HHS 1R011HG005095NHGRI NIH HHS R01 HG005095
6 · The paper itself

Abstract

In this work, DNA-Hg(II) interactions were investigated by monitoring the translocation of DNA hairpins in a protein ion channel in the absence and presence of metal ions. Our experiments demonstrate that target-specific hairpin structures could be stabilized much more significantly by mercuric ions than by the stem length and the loop size of the hairpin due to the formation of Thymine-Hg(II)-Thymine complexes. In addition, the designed DNA probe allows the development of a highly sensitive nanopore sensor for Hg(2+) with a detection limit of 25 nM. Further, the sensor is specific, and other tested metal ions including Pb(2+), Cu(2+), Cd(2+), and so on with concentrations of up to 2 orders of magnitude greater than that of Hg(2+) would not interfere with the mercury detection.

Indexed as

Electrochemical TechniquesNanoporesDNA ProbesHemolysin ProteinsInverted Repeat SequencesIonsLipid BilayersMercuryThymineDNA ProbesHemolysin ProteinsIonsLipid BilayersMercuryThymine

Identifiers

PMID23565989
PMCPMC3696130

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.