ReviewThe Journal of organic chemistry2013
Developing ligands for palladium(II)-catalyzed C-H functionalization: intimate dialogue between ligand and substrate.
Review in The Journal of organic chemistry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers.
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Who cites it
73 citing papers in PubMed.
- Alkyl-to-Alkyl Palladium Migration Enables Remote C-C Bond Formation.Journal of the American Chemical Society · 2026Article
- Transition Metal-Catalyzed Chemical Recycling and Upcycling of Polyethylene Terephthalate.ChemSusChem · 2026Review
- Aerobic C-H bond activation at a Pd center under aqueous conditions.Chemical science · 2026Article
- Granzyme B-mimetic nanozyme for nanovesicle targeted anticancer applications.Nature communications · 2026Article
- Mathematical Framework to Identify Optimal Molecule Based on Virtual Ligand Strategy.Journal of chemical information and modeling · 2025Article
- Article
- Article
- Acridine photocatalysis enables tricomponent direct decarboxylative amine construction.Chemical science · 2024Article
- Dual-Ligand Catalyst for the Nondirected C-H Olefination of Heteroarenes.Journal of the American Chemical Society · 2023Article
- β- and γ-C(spAngewandte Chemie (International ed. in English) · 2023Article
- Transient directing group enabled Pd-catalyzed C-H oxygenation of benzaldehydes and benzylic amines.RSC advances · 2022Article
- Palladium-Catalyzed Enantioselective β-C(spAccounts of chemical research · 2022Article
- Site-Selective Pd-Catalyzed C(spChemistry (Weinheim an der Bergstrasse, Germany) · 2021Article
- Advancing the Logic of Chemical Synthesis: C-H Activation as Strategic and Tactical Disconnections for C-C Bond Construction.Angewandte Chemie (International ed. in English) · 2021Review
- Facile synthesis of axially chiral styrene-type carboxylic acidsChemical science · 2021Article
- Temperature-modulated selective C(spChemical science · 2020Article
- Regiocontrol in the oxidative Heck reaction of indole by ligand-enabled switch of the regioselectivity-determining step.Chemical science · 2020Article
- Salient features of theChemical science · 2020Review
- Achieving Site-Selectivity for C-H Activation Processes Based on Distance and Geometry: A Carpenter's Approach.Journal of the American Chemical Society · 2020Review
- Ligand-Enabled Pd(II)-Catalyzed C(spOrganic letters · 2020Article
13 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Homogeneous transition-metal-catalyzed reactions are indispensable to all facets of modern chemical synthesis. It is thus difficult to imagine that for much of the early 20th century, the reactivity and selectivity of all known homogeneous metal catalysts paled in comparison to their heterogeneous and biological counterparts. In the intervening decades, advances in ligand design bridged this divide, such that today some of the most demanding bond-forming events are mediated by ligand-supported homogeneous metal species. While ligand design has propelled many areas of homogeneous catalysis, in the field of Pd(II)-catalyzed C-H functionalization, suitable ligand scaffolds are lacking, which has hampered the development of broadly practical transformations based on C-H functionalization logic. In this Perspective, we offer an account of our research employing three ligand scaffolds, mono-N-protected amino acids, 2,6-disubstituted pyridines, and 2,2'-bipyridines, to address challenges posed by several synthetically versatile substrate classes. Drawing on this work, we discuss principles of ligand design, such as the need to match a ligand to a particular substrate class, and how ligand traits such as tunability and modularity can be advantageous in reaction discovery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.