ArticleBehavioral neuroscience2013
The effects of acute nicotine, chronic nicotine, and withdrawal from chronic nicotine on performance of a cued appetitive response.
Article in Behavioral neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 22 citations in OpenAlex.
- Sex differences in tobacco smokers: Executive control network and frontostriatal connectivity.Drug and alcohol dependence · 2019Trial
- Estimation of Health Risks Caused by Metals Contained in E-Cigarette Aerosol through Passive Vaping.Toxics · 2023Article
- New Insights in the Involvement of the Endocannabinoid System and Natural Cannabinoids in Nicotine Dependence.International journal of molecular sciences · 2021Review
- Estimation of the dose of electronic cigarette chemicals deposited in human airways through passive vaping.Journal of exposure science & environmental epidemiology · 2021Article
- Cholinergic modulation of spatial learning, memory and navigation.The European journal of neuroscience · 2018Review
- Short-term nicotine exposure induces long-lasting modulation of gustatory plasticity inBiochemistry and biophysics reports · 2016Article
- c-Jun-N-terminal kinase 1 is necessary for nicotine-induced enhancement of contextual fear conditioning.Neuroscience letters · 2016Article
- Cognitive control deficits during mecamylamine-precipitated withdrawal in mice: Possible links to frontostriatal BDNF imbalance.Neurobiology of learning and memory · 2016Article
- Withdrawal From Chronic Nicotine Reduces Thyroid Hormone Levels and Levothyroxine Treatment Ameliorates Nicotine Withdrawal-Induced Deficits in Hippocampus-Dependent Learning in C57BL/6J Mice.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2015Article
- Nicotine Addiction and Psychiatric Disorders.International review of neurobiology · 2015Article
- Chronic nicotine attenuates phencyclidine-induced impulsivity in a mouse serial reaction time task.Behavioural brain research · 2014Article
- Cellular, molecular, and genetic substrates underlying the impact of nicotine on learning.Neurobiology of learning and memory · 2014Review
- Effects of Combined Nicotine and Caffeine on the Rat Skeletal Muscles: A Histological and Immunohistochemical Study.Journal of microscopy and ultrastructureArticle
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Nicotine is a widely used addictive drug, with an estimated 73 million Americans 12 years of age or older having used a tobacco product in the last month, despite documented risks to personal health. Nicotine alters cognitive processes, which include effects on attention and impulsivity, a mechanism that may contribute to the addictive properties of the drug. Individuals with a variety of psychological disorders ranging from attention deficit hyperactivity disorder (ADHD) to schizophrenia smoke at a higher rate than the rest of the population and show deficits in impulse control. The present studies evaluated the effects of acute, chronic, and withdrawal from chronic nicotine on an operant task that measured premature and signaled nose pokes, as well as performance efficiency in C57BL/6J mice. Results indicate that acute nicotine (0.09 mg/kg intraperitoneally) does not alter the acquisition of the task, but does significantly increase performance efficiency once the behavior has been learned. In contrast, chronic nicotine (0, 6.3, 12.6, and 36 mg/kg/day subcutaneously) and withdrawal from chronic nicotine had no effect on performance efficiency. These results suggest that initial nicotine use may have beneficial effects on inhibitory control, but these effects are not maintained with chronic nicotine consumption as tolerance develops. The findings may provide an explanation for higher rates of smoking in patients with impulse control issues, as the smoking may represent an initial attempt at self-medication.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.