ArticleBehavioral neuroscience2013
The medial preoptic area modulates cocaine-induced activity in female rats.
Article in Behavioral neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 61 citations in OpenAlex.
- The neurobiology of parenting and infant-evoked aggression.Physiological reviews · 2025Review
- Are There Connections between the Neuroendocrine and Dopamine Systems in Bipolar Disorder?Neuroendocrinology · 2025Review
- Effects of cabergoline and dimethylcabergoline on the sexual behavior of male rats.Psychopharmacology · 2024Article
- The medial preoptic area and its projections to the ventral tegmental area and the periaqueductal gray are activated in response to social play behavior in juvenile rats.Behavioral neuroscience · 2023Article
- The medial preoptic area and acute cocaine's stimulant effects in rats: Potential influences of estradiol and biological sex.Hormones and behavior · 2023Article
- Sex Steroid Hormone Receptor Content of Medial Preoptic Efferents to the Ventral Tegmental Area Is Sexually Dimorphic: Implications for Sex Differences in Mesolimbic Reward Processing.Neuroendocrinology · 2023Article
- The Genetic and Neural Substrates of Externalizing Behavior.Biological psychiatry global open science · 2022Article
- Glutamate in Male and Female Sexual Behavior: Receptors, Transporters, and Steroid Independence.Frontiers in behavioral neuroscience · 2020Review
- Differential disruption of conditioned ejaculatory preference in the male rat based on different sensory modalities by micro-infusions of naloxone to the medial preoptic area or ventral tegmental area.Psychopharmacology · 2019Article
- Copulation induces expression of the immediate early gene Arc in mating-relevant brain regions of the male rat.Behavioural brain research · 2019Article
- Estradiol increases choice of cocaine over food in male rats.Physiology & behavior · 2019Article
- VTA GABA Neurons at the Interface of Stress and Reward.Frontiers in neural circuits · 2019Review
- Estrogen Receptor β in the Nucleus Accumbens Regulates the Rewarding Properties of Cocaine in Female Mice.The international journal of neuropsychopharmacology · 2018Article
- Influence of preoptic estradiol on behavioral and neural response to cocaine in female Sprague-Dawley rats.Psychopharmacology · 2018Article
- Androgen Regulation of the Mesocorticolimbic System and Executive Function.Frontiers in endocrinology · 2018Review
- Hormonal gain control of a medial preoptic area social reward circuit.Nature neuroscience · 2017Article
- Integrating Neural Circuits Controlling Female Sexual Behavior.Frontiers in systems neuroscience · 2017Review
- The role of ΔfosB in the medial preoptic area: Differential effects of mating and cocaine history.Behavioral neuroscience · 2016Article
- Estradiol in the Preoptic Area Regulates the Dopaminergic Response to Cocaine in the Nucleus Accumbens.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Article
- The medial preoptic area modulates cocaine-induced locomotion in male rats.Behavioural brain research · 2016Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Drugs of abuse exert their effects by exploiting natural neurobiological reward mechanisms, especially the mesolimbic dopamine (DA) system. However, the mesolimbic system does not operate in isolation, and input from other reward-relevant structures may play a role in cocaine's rewarding effects. The medial preoptic area (mPOA) of the hypothalamus is involved in the regulation of two essential and naturally rewarding behaviors: sexual and maternal behaviors. It also makes strong neuroanatomical connections with areas of the mesolimbic system, particularly the ventral tegmental area (VTA). As such, the mPOA is a logical candidate for a neuroanatomical locus modulating activity in the mesolimbic system and emergent behavioral expressions of drug reward, yet the role of this structure is largely unexplored. Here, using a female rat model, we show that the mPOA innervates the VTA in a region-specific manner, that lesions of the mPOA augment cocaine-induced Fos expression in the nucleus accumbens (NAc) and cocaine-induced conditioned place preference. We also show that approximately 68% of mPOA-VTA efferents release γ-aminobutyric acid (GABA), over 75% are sensitive to DA as evidenced by colocalization with DA receptors, and nearly 60% of these contain both DA receptors and GABA, which suggests a novel key role for the mPOA in the inhibition of the mesolimbic DA circuit. Combined, these results reveal the mPOA as a critical modulating structure in cocaine-induced mesolimbic activity and behavioral manifestation of reward, at least in part, via GABAergic output that is sensitive to DA input.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.