ArticleJournal of the American Chemical Society2013
Charged gold nanoparticles with essentially zero serum protein adsorption in undiluted fetal bovine serum.
Article in Journal of the American Chemical Society, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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Who cites it
22 citing papers in PubMed, 84 citations in OpenAlex.
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- Controlling the pyridinium-zwitterionic ligand ratio on atomically precise gold nanoclusters allowing for eradicating Gram-positive drug-resistant bacteria and retaining biocompatibility.Chemical science · 2021Article
- Embracing nanomaterials' interactions with the innate immune system.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2021Review
- Employing defined bioconjugates to generate chemically functionalised gold nanoparticles forNanoscale · 2021Article
- Biomolecular interactions of ultrasmall metallic nanoparticles and nanoclusters.Nanoscale advances · 2021Review
- The effect of size, charge, and peptide ligand length on kidney targeting by small, organic nanoparticles.Bioengineering & translational medicine · 2020Article
- Impact of Anti-Biofouling Surface Coatings on the Properties of Nanomaterials and Their Biomedical Applications.Journal of materials chemistry. B · 2018Article
- Short-chained oligo(ethylene oxide)-functionalized gold nanoparticles: realization of significant protein resistance.Analytical and bioanalytical chemistry · 2018Article
- Molecular dynamics simulations on the effect of size and shape on the interactions between negative AuColloids and surfaces. A, Physicochemical and engineering aspects · 2016Article
- Biointeractions of ultrasmall glutathione-coated gold nanoparticles: effect of small size variations.Nanoscale · 2016Article
- Using the Power of Organic Synthesis for Engineering the Interactions of Nanoparticles with Biological Systems.Nano today · 2016Article
- Generic, phenomenological, on-the-fly renormalized repulsion model for self-limited organization of terminal supraparticle assemblies.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Reversibly extracellular pH controlled cellular uptake and photothermal therapy by PEGylated mixed-charge gold nanostars.Small (Weinheim an der Bergstrasse, Germany) · 2015Article
- Nanometric resolution in the hydrodynamic size analysis of ligand-stabilized gold nanorods.Langmuir : the ACS journal of surfaces and colloids · 2014Article
- Article
- Quenched Assembly of NIR-Active Gold Nanoclusters Capped with Strongly Bound Ligands by Tuning Particle Charge via pH and Salinity.The journal of physical chemistry. C, Nanomaterials and interfaces · 2014Article
- Terminal supraparticle assemblies from similarly charged protein molecules and nanoparticles.Nature communications · 2014Article
- 'Living' PEGylation on gold nanoparticles to optimize cancer cell uptake by controlling targeting ligand and charge densities.Nanotechnology · 2013Article
- Feasibility study of brain tumor delineation using immunolabeled gold nanorods.Biomedical optics express · 2013Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
The adsorption of even a single serum protein molecule on a gold nanosphere used in biomedical imaging may increase the size too much for renal clearance. In this work, we designed charged ~5 nm Au nanospheres coated with binary mixed-charge ligand monolayers that do not change in size upon incubation in pure fetal bovine serum (FBS). This lack of protein adsorption was unexpected in view of the fact that the Au surface was moderately charged. The mixed-charge monolayers were composed of anionic citrate ligands modified by place exchange with naturally occurring amino acids: either cationic lysine or zwitterionic cysteine ligands. The zwitterionic tips of either the lysine or cysteine ligands interact weakly with the proteins and furthermore increase the distance between the "buried" charges closer to the Au surface and the interacting sites on the protein surface. The ~5 nm nanospheres were assembled into ~20 nm diameter nanoclusters with strong near-IR absorbance (of interest in biomedical imaging and therapy) with a biodegradable polymer, PLA(1k)-b-PEG(10k)-b-PLA(1k). Upon biodegradation of the polymer in acidic solution, the nanoclusters dissociated into primary ~5 nm Au nanospheres, which also did not adsorb any detectable serum protein in undiluted FBS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.