ArticlePloS one2013
Increased iron loading induces Bmp6 expression in the non-parenchymal cells of the liver independent of the BMP-signaling pathway.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed.
- Iron chaperones and RNA-binding proteins, PCBP1 and PCBP2, maintain hepatic iron balance and protect against ferroptosis.Free radical biology & medicine · 2026Article
- Halofuginone suppresses hepcidin by a heparan sulfate-dependent mechanism to treat iron disorders in mice.Blood advances · 2026Article
- Xanthan Gum-Iron System: Natural, Mechanically Tunable, Bioactive, and Magnetic-Responsive Hydrogels for Biomedical Engineering Applications.ACS applied materials & interfaces · 2025Article
- BMP6 participates in the molecular mechanisms involved in APAP hepatotoxicity.Archives of toxicology · 2025Article
- Reduced Plasma Bone Morphogenetic Protein 6 Levels in Sepsis and Septic Shock Patients.Biomedicines · 2024Article
- Comparison of the effects of high dietary iron levels on bone microarchitecture responses in the mouse strains 129/Sv and C57BL/6J.Scientific reports · 2024Article
- The iron chaperone poly(rC)-binding protein 1 regulates iron efflux through intestinal ferroportin in mice.Blood · 2023Article
- Clinical Significance of Erythroferrone and Bone Morphogenetic Protein-6 in Patients with Anemia in the Course of Inflammatory Bowel Disease.Metabolites · 2023Article
- Article
- Vitamin E Induces Liver Iron Depletion and Alters Iron Regulation in Mice.The Journal of nutrition · 2023Article
- Mitochondrial dysfunction in mouse livers depleted of iron chaperone PCBP1.Free radical biology & medicine · 2021Article
- Inflaming the Brain with Iron.Antioxidants (Basel, Switzerland) · 2021Review
- Orphan Nuclear Receptor ERRγ Is a Novel Transcriptional Regulator of IL-6 Mediated Hepatic BMP6 Gene Expression in Mice.International journal of molecular sciences · 2020Article
- A Short Review of Iron Metabolism and Pathophysiology of Iron Disorders.Medicines (Basel, Switzerland) · 2019Review
- The catalytic, stem, and transmembrane portions of matriptase-2 are required for suppressing the expression of the iron-regulatory hormone hepcidin.The Journal of biological chemistry · 2019Article
- Hepcidin-ferroportin axis in health and disease.Vitamins and hormones · 2019Review
- Effect of stimulated erythropoiesis on liver SMAD signaling pathway in iron-overloaded and iron-deficient mice.PloS one · 2019Article
- Circulating iron levels influence the regulation of hepcidin following stimulated erythropoiesis.Haematologica · 2018Article
- Iron homeostasis: An anthropocentric perspective.The Journal of biological chemistry · 2017Review
- Bone morphogenetic protein-binding endothelial regulator of liver sinusoidal endothelial cells induces iron overload in a fatty liver mouse model.Journal of gastroenterology · 2017Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Bone morphogenetic protein 6 (BMP6) is an essential cytokine for the expression of hepcidin, an iron regulatory hormone secreted predominantly by hepatocytes. Bmp6 expression is upregulated by increased iron-levels in the liver. Both hepatocytes and non-parenchymal liver cells have detectable Bmp6 mRNA. Here we showed that induction of hepcidin expression in hepatocytes by dietary iron is associated with an elevation of Bmp6 mRNA in the non-parenchymal cells of the liver. Consistently, incubation with iron-saturated transferrin induces Bmp6 mRNA expression in isolated hepatic stellate cells, but not in hepatocytes. These observations suggest an important role of the non-parenchymal liver cells in regulating iron-homeostasis by acting as a source of Bmp6.
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