ArticlePloS one2013
First genome-wide association study on anxiety-related behaviours in childhood.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 3 of them syntheses that pooled it.
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Who cites it
34 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Genome-wide Association Meta-analysis of Childhood and Adolescent Internalizing Symptoms.Journal of the American Academy of Child and Adolescent Psychiatry · 2022Pooled it
- Genetic Overlap Between Schizophrenia and Developmental Psychopathology: Longitudinal and Multivariate Polygenic Risk Prediction of Common Psychiatric Traits During Development.Schizophrenia bulletin · 2017Pooled it
- Pooled it
- Psychological strains after the crisis: evaluating separation anxiety among Iranian children and adolescents in the post-COVID-19 era.BMC psychology · 2024Article
- The genetic architecture of youth anxiety: a study protocol.BMC psychiatry · 2024Article
- Exploring the association of interleukin polymorphisms with aggression and internalizing behaviors in children and adolescents.Brain and behavior · 2022Article
- Phenome risk classification enables phenotypic imputation and gene discovery in developmental stuttering.American journal of human genetics · 2021Article
- Gene-environment interaction: New insights into perceived parenting and social anxiety among adolescents.European psychiatry : the journal of the Association of European Psychiatrists · 2020Article
- Polygenic score for educational attainment captures DNA variants shared between personality traits and educational achievement.Journal of personality and social psychology · 2019Article
- The genetic and environmental structure of fear and anxiety in juvenile twins.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2019Article
- Genetics of Anxiety Disorders.Current psychiatry reports · 2019Review
- Extracting stability increases the SNP heritability of emotional problems in young people.Translational psychiatry · 2018Article
- Sociogenomics in the 21Sociology compass · 2018Article
- Individual and shared effects of social environment and polygenic risk scores on adolescent body mass index.Scientific reports · 2018Article
- Childhood behaviour problems show the greatest gap between DNA-based and twin heritability.Translational psychiatry · 2017Article
- Relationship of Genetic Variants With Procedural Pain, Anxiety, and Distress in Children.Biological research for nursing · 2017Article
- Genome-wide association study of generalized anxiety symptoms in the Hispanic Community Health Study/Study of Latinos.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2017Article
- Genetic link between family socioeconomic status and children's educational achievement estimated from genome-wide SNPs.Molecular psychiatry · 2016Article
- A Genome-Wide Test of the Differential Susceptibility Hypothesis Reveals a Genetic Predictor of Differential Response to Psychological Treatments for Child Anxiety Disorders.Psychotherapy and psychosomatics · 2016Article
- The Genetics of Stress-Related Disorders: PTSD, Depression, and Anxiety Disorders.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Review
Corrections and comments
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Authors and funding
9 authors.
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Abstract
backgroundTwin studies have shown that anxiety in a general population sample of children involves both domain-general and trait-specific genetic effects. For this reason, in an attempt to identify genes responsible for these effects, we investigated domain-general and trait-specific genetic associations in the first genome-wide association (GWA) study on anxiety-related behaviours (ARBs) in childhood.
methodsThe sample included 2810 7-year-olds drawn from the Twins Early Development Study (TEDS) with data available for parent-rated anxiety and genome-wide DNA markers. The measure was the Anxiety-Related Behaviours Questionnaire (ARBQ), which assesses four anxiety traits and also yields a general anxiety composite. Affymetrix GeneChip 6.0 DNA arrays were used to genotype nearly 700,000 single-nucleotide polymorphisms (SNPs), and IMPUTE v2 was used to impute more than 1 million SNPs. Several GWA associations from this discovery sample were followed up in another TEDS sample of 4804 children. In addition, Genome-wide Complex Trait Analysis (GCTA) was used on the discovery sample, to estimate the total amount of variance in ARBs that can be accounted for by SNPs on the array.
resultsNo SNP associations met the demanding criterion of genome-wide significance that corrects for multiple testing across the genome (p<5×10(-8)). Attempts to replicate the top associations did not yield significant results. In contrast to the substantial twin study estimates of heritability which ranged from 0.50 (0.03) to 0.61 (0.01), the GCTA estimates of phenotypic variance accounted for by the SNPs were much lower 0.01 (0.11) to 0.19 (0.12).
conclusionsTaken together, these GWAS and GCTA results suggest that anxiety--similar to height, weight and intelligence--is affected by many genetic variants of small effect, but unlike these other prototypical polygenic traits, genetic influence on anxiety is not well tagged by common SNPs.
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