Evidence map›Paper›PMID 23565122›Full record

ArticleInternational journal of biomedical engineering and technology2012

Ultrasonic wave propagation assessment of native cartilage explants and hydrogel scaffolds for tissue engineering.

Sean S Kohles, Shelley S Mason, Anya P Adams, Robert J Berg, Jessica Blank, Fay Gibson, Johnathan Righetti, Iesha S Washington, Asit K Saha

Open access · greenAbstract read
In one paragraph

Article in International journal of biomedical engineering and technology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
0.2field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Sean S KohlesRegenerative Bioengineering Laboratory, Departments of Mechanical & Materials Engineering and Biology, Portland State University, Portland, Oregon, USA.
Shelley S Mason
Anya P Adams
Robert J Berg
Jessica Blank
Fay Gibson
Johnathan Righetti
Iesha S Washington
Asit K Saha
Portland State University · USCentral State University · US

Funding

Research TechnologyP20MD003350 · NIMHD · CENTRAL STATE UNIV (WILBERFORCE, OH) · PI JACKSONHAMMOND, CYNTHIA · 2008 to 2012
$4.2M
NIMHD NIH HHS P20 MD003350
6 · The paper itself

Abstract

Non-destructive techniques characterising the mechanical properties of cells, tissues, and biomaterials provide baseline metrics for tissue engineering design. Ultrasonic wave propagation and attenuation has previously demonstrated the dynamics of extracellular matrix synthesis in chondrocyte-seeded hydrogel constructs. In this paper, we describe an ultrasonic method to analyse two of the construct elements used to engineer articular cartilage in real-time, native cartilage explants and an agarose biomaterial. Results indicated a similarity in wave propagation velocity ranges for both longitudinal (1500-1745 m/s) and transverse (350-950 m/s) waveforms. Future work will apply an acoustoelastic analysis to distinguish between the fluid and solid properties including the cell and matrix biokinetics as a validation of previous mathematical models.

Indexed as

acoustoelasticitybioengineeringbiomedical engineeringcartilage biokineticscartilage engineeringhydrogel biomaterialstransmission wave elasticityultrasonic elasticity

Identifiers

PMID23565122
PMCPMC3615726
OpenAlexW2084394778

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.