ArticleFrontiers in physiology2013
Band-like arrangement of taste-like sensory cells at the gastric groove: evidence for paracrine communication.
Article in Frontiers in physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 24 citations in OpenAlex.
- Potential role of glucagon like peptide 1 in taste receptors.Frontiers in endocrinology · 2025Review
- Tuft Cells Increase Following Ovine Intestinal Parasite Infections and Define Evolutionarily Conserved and Divergent Responses.Frontiers in immunology · 2021Article
- Advillin is a tuft cell marker in the mouse alimentary tract.Journal of molecular histology · 2020Article
- Distinct Cell Types With the Bitter Receptor Tas2r126 in Different Compartments of the Stomach.Frontiers in physiology · 2020Article
- Tuft Cells-Systemically Dispersed Sensory Epithelia Integrating Immune and Neural Circuitry.Annual review of immunology · 2019Review
- Unique Cellular Lineage Composition of the First Gland of the Mouse Gastric Corpus.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2017Article
- Members of Bitter Taste Receptor ClusterFrontiers in physiology · 2017Article
- Chemical coding and chemosensory properties of cholinergic brush cells in the mouse gastrointestinal and biliary tract.Frontiers in physiology · 2015Article
- High fat feeding affects the number of GPR120 cells and enteroendocrine cells in the mouse stomach.Frontiers in physiology · 2015Article
- Cholinergic epithelial cell with chemosensory traits in murine thymic medulla.Cell and tissue research · 2014Article
- Receptors for short-chain fatty acids in brush cells at the "gastric groove".Frontiers in physiology · 2014Article
- Pou2f3/Skn-1a is necessary for the generation or differentiation of solitary chemosensory cells in the anterior nasal cavity.Bioscience, biotechnology, and biochemistry · 2013Article
- Putative interaction of brush cells with bicarbonate secreting cells in the proximal corpus mucosa.Frontiers in physiology · 2013Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The discovery of taste-related elements within the gastrointestinal tract has led to a growing interest in the mechanisms and physiological significance of chemosensory monitoring of chymus composition. Previous work suggests that brush cells located in the "gastric groove," which parallels the "limiting ridge," a structure in rodents that divides the fundus from the corpus, are candidate sensory cells. A novel sectioning technique revealed that these cells are arranged in a palisade-like manner forming a band which borders the whole length of the corpus epithelium. Using transgenic PLCβ2 promoter-GFP mice and specific antibodies, we have demonstrated that most of these cells express gustducin, PLCβ2, and TRPM5; typical signaling proteins of gustatory sensory "type II" cells. These molecular features strongly suggest that the cells may be capable of sensing nutrient or non-nutrient constituents of the ingested food. Since there is no evidence that brush cells are endocrine cells, attempts were made to explore how such putative chemosensory cells might transmit the information to "effector" cells. It was found that most of the cells express the neuronal nitric oxide synthase (NOS) suggesting some paracrine interaction with adjacent cells. Moreover, they also express choline acetyltransferase (ChAT) as well as the vesicular protein SNAP25, indicating the potential for cholinergic transmission, possibly with subjacent enteric nerve fibers.
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