ArticleMolecular biology and evolution2013
Twisted signatures of GC-biased gene conversion embedded in an evolutionary stable karyotype.
Article in Molecular biology and evolution, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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27 citing papers in PubMed, 45 citations in OpenAlex.
- The GC% landscape of the Nucleocytoviricota.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2024Article
- The role of recombination dynamics in shaping signatures of direct and indirect selection across theProceedings. Biological sciences · 2024Article
- GC-biased gene conversion drives accelerated evolution of ultraconserved elements in mammalian and avian genomes.Genome research · 2023Article
- Extreme variation in recombination rate and genetic diversity along the Sylvioidea neo-sex chromosome.Molecular ecology · 2022Article
- Linked-Read Sequencing of Eight Falcons Reveals a Unique Genomic Architecture in Flux.Genome biology and evolution · 2022Article
- Runaway GC Evolution in Gerbil Genomes.Molecular biology and evolution · 2020Article
- Adapting Biased Gene Conversion theory to account for intensive GC-content deterioration in the human genome by novel mutations.PloS one · 2020Article
- Influence of Recombination and GC-biased Gene Conversion on the Adaptive and Nonadaptive Substitution Rate in Mammals versus Birds.Molecular biology and evolution · 2019Article
- GC-biased gene conversion conceals the prediction of the nearly neutral theory in avian genomes.Genome biology · 2019Article
- Biased Inference of Selection Due to GC-Biased Gene Conversion and the Rate of Protein Evolution in Flycatchers When Accounting for It.Molecular biology and evolution · 2018Article
- 1000 human genomes carry widespread signatures of GC biased gene conversion.BMC genomics · 2018Article
- Determinants of the Efficacy of Natural Selection on Coding and Noncoding Variability in Two Passerine Species.Genome biology and evolution · 2017Article
- Covariation in levels of nucleotide diversity in homologous regions of the avian genome long after completion of lineage sorting.Proceedings. Biological sciences · 2017Article
- Evolution of heterogeneous genome differentiation across multiple contact zones in a crow species complex.Nature communications · 2016Article
- High-Resolution Mapping of Crossover and Non-crossover Recombination Events by Whole-Genome Re-sequencing of an Avian Pedigree.PLoS genetics · 2016Article
- Recombination Rate Variation Modulates Gene Sequence Evolution Mainly via GC-Biased Gene Conversion, Not Hill-Robertson Interference, in an Avian System.Molecular biology and evolution · 2016Article
- Stable recombination hotspots in birds.Science (New York, N.Y.) · 2015Article
- Evolutionary consequences of DNA methylation on the GC content in vertebrate genomes.G3 (Bethesda, Md.) · 2015Article
- Biased gene conversion and GC-content evolution in the coding sequences of reptiles and vertebrates.Genome biology and evolution · 2014Article
- Whole-genome analyses resolve early branches in the tree of life of modern birds.Science (New York, N.Y.) · 2014Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The genomes of many vertebrates show a characteristic heterogeneous distribution of GC content, the so-called GC isochore structure. The origin of isochores has been explained via the mechanism of GC-biased gene conversion (gBGC). However, although the isochore structure is declining in many mammalian genomes, the heterogeneity in GC content is being reinforced in the avian genome. Despite this discrepancy, which remains unexplained, examinations of individual substitution frequencies in mammals and birds are both consistent with the gBGC model of isochore evolution. On the other hand, a negative correlation between substitution and recombination rate found in the chicken genome is inconsistent with the gBGC model. It should therefore be important to consider along with gBGC other consequences of recombination on the origin and fate of mutations, as well as to account for relationships between recombination rate and other genomic features. We therefore developed an analytical model to describe the substitution patterns found in the chicken genome, and further investigated the relationships between substitution patterns and several genomic features in a rigorous statistical framework. Our analysis indicates that GC content itself, either directly or indirectly via interrelations to other genomic features, has an impact on the substitution pattern. Further, we suggest that this phenomenon is particularly visible in avian genomes due to their unusually low rate of chromosomal evolution. Because of this, interrelations between GC content and other genomic features are being reinforced, and are as such more pronounced in avian genomes as compared with other vertebrate genomes with a less stable karyotype.
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