Evidence map›Paper›PMID 23564686›Full record

ArticleCurrent protocols in immunology2013

Autoimmune myocarditis, valvulitis, and cardiomyopathy.

Jennifer M Myers, DeLisa Fairweather, Sally A Huber, Madeleine W Cunningham

Open access · greenAbstract read
In one paragraph

Article in Current protocols in immunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 63 citations in OpenAlex.

  1. Article
  2. Tnni3k Is Cardioprotective in Viral Myocarditis.Journal of cardiovascular development and disease · 2026
    Article
  3. Mapping myocarditis in three dimensions.Cardiovascular research · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. T-Cell Receptor Sequences Identify Combined Coxsackievirus-International journal of molecular sciences · 2024
    Article
  9. The inflammatory spectrum of cardiomyopathies.Frontiers in cardiovascular medicine · 2024
    Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Review
  18. Review
  19. Article
  20. Sex and age differences in sST2 in cardiovascular disease.Frontiers in cardiovascular medicine · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Jennifer M MyersUniversity of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
DeLisa Fairweather
Sally A Huber
Madeleine W Cunningham
University of Oklahoma Health Sciences Center · USJohns Hopkins University · USUniversity of Vermont · US

Funding

AUTOIMMUNE DETERMINANTS OF HUMAN CARDIAC MYOSINR01HL056267 · NHLBI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI COOPER, LESLIE T, CUNNINGHAM, MADELEINE W. · 1997 to 2013
$4.7M
Molecular Basis of Immunity - Kirschtein-NRSAT32AI007633 · NIAID · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI CUNNINGHAM, MADELEINE W. · 2001 to 2022
$4.0M
MYOSIN--A LINK BETWEEN STREPTOCOCCI AND HEARTR37HL035280 · NHLBI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI CUNNINGHAM, MADELEINE W. · 1999 to 2008
$3.0M
Regulating heart disease: the adjuvant effect of viral infection.R01HL087033 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI FAIRWEATHER, DELISA · 2007 to 2011
$2.5M
Sex Differences in Complement during Myocarditis/DCMR01HL111938 · NHLBI · MAYO CLINIC JACKSONVILLE · PI FAIRWEATHER, DELISA · 2012 to 2015
$1.6M
Tregulatory cells in myocarditisR01HL108371 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI HUBER, SALLY A · 2011 to 2014
$1.5M
Autoimmune Determinants of Human Cardiac MyosinR56HL056267 · NHLBI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI COOPER, LESLIE T, CUNNINGHAM, MADELEINE W. · 2008 to 2015
$933k
NHLBI NIH HHS HL111938NHLBI NIH HHS R01 HL056267NHLBI NIH HHS R01HL056267NHLBI NIH HHS R01 HL087033NHLBI NIH HHS R01HL087033NHLBI NIH HHS R01HL108371NHLBI NIH HHS R01 HL111938NHLBI NIH HHS R37 HL035280NHLBI NIH HHS R37HL035280NHLBI NIH HHS R56 HL056267NIAID NIH HHS T32 AI007633
6 · The paper itself

Abstract

Myocarditis and valvulitis are inflammatory diseases affecting myocardium and valve. Myocarditis, a viral-induced disease of myocardium, may lead to dilated cardiomyopathy and loss of heart function. Valvulitis leads to deformed heart valves and altered blood flow in rheumatic heart disease. Animal models recapitulating these diseases are important in understanding the human condition. Cardiac myosin is a major autoantigen in heart, and antibodies and T cells to cardiac myosin are evident in inflammatory heart diseases. This unit is a practical guide to induction and evaluation of experimental autoimmune myocarditis (EAM) in several mouse strains and the Lewis rat. Purification protocols for cardiac myosin and protocols for induction of EAM by cardiac myosin and its myocarditis-producing peptides, and coxsackievirus CVB3, are defined. Protocols for assessment of myocarditis and valvulitis in humans and animal models provide methods to define functional autoantibodies targeting cardiac myosin, β-adrenergic, and muscarinic receptors, and their deposition in tissues.

Indexed as

AutoimmunityDisease Models, AnimalAnimalsAutoantibodiesAutoantigensAutoimmune DiseasesCardiac MyosinsCardiomyopathiesCoxsackievirus InfectionsEnterovirusGene ExpressionHeart ValvesHumansInflammationMiceMyocarditisAutoantibodiesAutoantigensCardiac MyosinsReceptors, Adrenergic, betaReceptors, Muscarinic

Identifiers

PMID23564686
PMCPMC3672855
OpenAlexW1627734560

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.