ArticleCirculation. Cardiovascular imaging2013
In vivo magnetization transfer and diffusion-weighted magnetic resonance imaging detects thrombus composition in a mouse model of deep vein thrombosis.
Article in Circulation. Cardiovascular imaging, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- A systematic review evaluating imaging techniques to determine chronicity of deep vein thrombosis.Phlebology · 2026Pooled it
- A Multicenter MRI Protocol for the Evaluation and Quantification of Deep Vein Thrombosis.Journal of visualized experiments : JoVE · 2015Trial
- Molecular MRI of Collagen Enables Evaluation of Fibrosis and Therapeutic Response in Venous Thrombosis.Circulation. Cardiovascular imaging · 2026Article
- Seeing the Unseen: Contrast-Free MRI for Predicting Thrombolytic Susceptibility.Circulation. Cardiovascular imaging · 2025Article
- Multiparametric Contrast-Free MRI Successfully Identifies Venous Thrombus Responsive to Lytic Therapy: From Mice to Humans.Circulation. Cardiovascular imaging · 2025Article
- Quantitative assessment of thrombosis-induced blood oxygenation change in deep tissues based on photoacoustic tomography: anBiomedical optics express · 2025Article
- Magnetic resonance (MR) evaluation of deep venous thrombosis of 338 discharged viral pneumonia patients.Quantitative imaging in medicine and surgery · 2024Article
- Ferumoxytol-enhanced MRI assessment of venous Thrombus resolution and macrophage content in a murine deep vein thrombosis model.Thrombosis research · 2024Article
- Experimental multiparametric magnetic resonance imaging characterization of iliocaval venous thrombosis pathological changes.Journal of vascular surgery. Venous and lymphatic disorders · 2024Article
- An Intermodal Correlation Study among Imaging, Histology, Procedural and Clinical Parameters in Cerebral Thrombi Retrieved from Anterior Circulation Ischemic Stroke Patients.Journal of clinical medicine · 2022Article
- Detection and Characterization of Thrombosis in Humans Using Fibrin-Targeted Positron Emission Tomography and Magnetic Resonance.JACC. Cardiovascular imaging · 2022Article
- Thrombus Structural Composition in Cardiovascular Disease.Arteriosclerosis, thrombosis, and vascular biology · 2021Review
- Contrast-free high-resolution 3D magnetization transfer imaging for simultaneous myocardial scar and cardiac vein visualization.Magma (New York, N.Y.) · 2020Article
- High Signal Intensity on Diffusion-Weighted Images Reflects Acute Phase of Deep Vein Thrombus.Thrombosis and haemostasis · 2020Article
- DANTE-SPACE: a new technical tool for DVT on 1.5T MRI.The international journal of cardiovascular imaging · 2019Article
- Diffusion weighted cardiovascular magnetic resonance imaging for discriminating acute from non-acute deep venous Thrombus.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2019Article
- An unmet clinical need: The history of thrombus imaging.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2019Review
- Diffusion-weighted imaging in acute pulmonary embolism: a feasibility study.Acta radiologica open · 2018Article
- The use of diffusion weighted imaging to evaluate pathology outside the brain parenchyma in neuroimaging studies.The British journal of radiology · 2017Review
- Advanced imaging in acute and chronic deep vein thrombosis.Cardiovascular diagnosis and therapy · 2016Review
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundDeep vein thrombosis remains a major health problem necessitating accurate diagnosis. Thrombolysis is associated with significant morbidity and is effective only for the treatment of unorganized thrombus. We tested the feasibility of in vivo magnetization transfer (MT) and diffusion-weighted magnetic resonance imaging to detect thrombus organization in a murine model of deep vein thrombosis. METHODS AND
resultsDeep vein thrombosis was induced in the inferior vena cava of male BALB/C mice. Magnetic resonance imaging was performed at days 1, 7, 14, 21, and 28 after thrombus induction using MT, diffusion-weighted, inversion-recovery, and T1-mapping protocols. Delayed enhancement and T1 mapping were repeated 2 hours after injection of a fibrin contrast agent. Finally, excised thrombi were used for histology. We found that MT and diffusion-weighted imaging can detect histological changes associated with thrombus aging. MT rate (MTR) maps and percentage of MT rate (%MTR) allowed visualization and quantification of the thrombus protein content, respectively. The %MTR increased with thrombus organization and was significantly higher at days 14, 21, and 28 after thrombus induction (days 1, 7, 14, 21, 28: %MTR=2483±451, 2079±1210, 7029±2490, 10 295±4356, 32 994±25 449; PANOVA<0.05). There was a significant positive correlation between the %MTR and the histological protein content of the thrombus (r=0.70; P<0.05). The apparent diffusion coefficient was lower in erythrocyte-rich and collagen-rich thrombus (0.72±0.10 and 0.69±0.05 [×10(-3) mm(2)/s]). Thrombus at days 7 and 14 had the highest apparent diffusion coefficient values (0.95±0.09 and 1.10±0.18 [×10(-3) mm(2)/s]).
conclusionsMT and diffusion-weighted magnetic resonance imaging sequences are promising for the staging of thrombus composition and could be useful in guiding medical intervention.
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