ArticleEndocrine2014
"Is there any association between insulin resistance and thyroid cancer? : A case control study".
Article in Endocrine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Pooled it
- A Comprehensive Mendelian Randomization Study Investigating Multiple Exposures and Outcomes: Focusing on Nontoxic Goitre and Type 2 Diabetes Mellitus.Clinical endocrinology · 2025Article
- Metabolic obesity phenotypes and thyroid cancer risk: A systematic exploration of the evidence.Obesity science & practice · 2024Review
- Obesity and thyroid cancer: unraveling the connection through a systematic review and meta-analysis of cohort studies.Journal of diabetes and metabolic disorders · 2024Review
- Analysis of risk factors for papillary thyroid carcinoma and the association with thyroid function indicators.Frontiers in endocrinology · 2024Article
- Effects of Metformin Therapy on Thyroid Volume and Functions in Patients with Newly Diagnosed Type 2 Diabetes Mellitus: A Single-center Prospective Study.Endocrine, metabolic & immune disorders drug targets · 2024Observational
- Clinical characteristics and therapeutic response of differentiated thyroid carcinoma with obesity and diabetes.BMC cancer · 2023Article
- Carbohydrate, Lipid, and Apolipoprotein Biomarkers in Blood and Risk of Thyroid Cancer: Findings from the AMORIS Cohort.Cancers · 2023Article
- Relationship between insulin resistance and thyroid cancer in Chinese euthyroid subjects without conditions affecting insulin resistance.BMC endocrine disorders · 2022Article
- Abnormal Glucose Metabolism Parameters and the Aggressiveness of Differentiated Thyroid Carcinoma: A Hospital-Based Cross-Section Study in China.Frontiers in endocrinology · 2022Observational
- The prevalence and associated predictors for Bethesda III-VI for reporting thyroid cytopathology in Royal Commission Hospital, Kingdom of Saudi Arabia.Therapeutic advances in endocrinology and metabolism · 2022Article
- Serum Adiponectin and Progranulin Level in Patients with Benign Thyroid Nodule or Papillary Thyroid Cancer.Endocrinology and metabolism (Seoul, Korea) · 2020Article
- Association of obesity and diabetes with thyroid nodules.Endocrine · 2018Observational
- Insulin Resistance Associated With Differentiated Thyroid Carcinoma: Penalized Conditional Logistic Regression Analysis of a Matched Case-Control Study Data.International journal of endocrinology and metabolism · 2018Article
- The Association of Thyroid Nodules with Metabolic Status: A Cross-Sectional SPECT-China Study.International journal of endocrinology · 2018Article
- Observational
- Insulin resistance is another factor that increases the risk of recurrence in patients with thyroid cancer.Endocrine · 2015Article
- Higher body mass index may be a predictor of extrathyroidal extension in patients with papillary thyroid microcarcinoma.Endocrine · 2015Article
- Investigation of insulin resistance gene polymorphisms in patients with differentiated thyroid cancer.Molecular biology reports · 2014Article
- THYROID NODULE FREQUENCY AND MALIGNANCY RISK ACCORDING TO ATA- 2015 AND ACR-TI-RADS CLASSIFICATION IN OBESE PATIENTS.Acta endocrinologica (Bucharest, Romania : 2005)Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Insulin stimulates proliferation of thyroid cells in culture. The presence of insulin resistance (IR) is associated with larger thyroid gland volume and an increased prevalence of thyroid nodules. The aim of this study was to investigate the presence of any possible association between IR and thyroid cancer. Forty-one patients with diffuse thyroid cancer (Group 1) were matched for age and gender with 41 patients with nodular goiter (Group 2). Both groups were compared in terms of frequency of IR, as estimated by the homeostasis model assessment, as well as other parameters of the metabolic syndrome (MetS). Fourteen patients (34.1 %) in each group had MetS. Twelve patients (29.3 %) in group 1 had IR compared to 10 (24.4 %) in group 2. Mean HOMA-IR scores in group 1 and 2 were 2.5 ± 2.2 and 1.8 ± 1.1, respectively. Thirty-two patients (78 %) in group 1 had a body mass index (BMI) of more than 25 compared to 33 patients (80.5 %) in group 2. The difference between groups with regard to HOMA-IR, the frequency of IR, BMI, and any of the parameters of MetS was statistically insignificant (p > 0.05). A subgroup analysis based on tumor size did not reveal a significant difference between patients with microcarcinoma (≤10 mm) and macrocarcinoma (>10 mm) in terms of any of the study parameters (p > 0.05). Neither MetS nor IR was a significant risk factor for thyroid cancer following logistic regression analysis (p > 0.05). IR is not more prevalent in patients with thyroid cancer. Some other pathologic mechanisms may be more prominent during thyroid carcinogenesis.
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