ArticleNeuromolecular medicine2013
An association study on renalase polymorphisms and ischemic stroke in a Chinese population.
Article in Neuromolecular medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Association of Renalase SNPs rs2296545 and rs2576178 with the Risk of Hypertension: A Meta-Analysis.PloS one · 2016Pooled it
- Renalase gene Glu37Asp polymorphism affects susceptibility to diabetic retinopathy in type 2 diabetes mellitus.Acta diabetologica · 2021Article
- The Effect of Renalase rs2576178 and rs10887800 Polymorphisms on Ischemic Stroke Susceptibility in Young Patients (<50 Years): A Case-Control Study and In Silico Analysis.Disease markers · 2021Article
- Integrate Molecular Phenome and Polygenic Interaction to Detect the Genetic Risk of Ischemic Stroke.Frontiers in cell and developmental biology · 2020Article
- Investigation of Renalase gene rs2576178 polymorphism in patients with coronary artery disease.Bioscience reports · 2018Article
- Novel CD137 Gene Polymorphisms and Susceptibility to Ischemic Stroke in the Northern Chinese Han Population.Neuromolecular medicine · 2017Article
- Extracellular renalase protects cells and organs by outside-in signalling.Journal of cellular and molecular medicine · 2017Review
- A Novel Association of the Suppressor of Cytokine Signaling 1 (SOCS1) Gene Polymorphisms in Ischemic Stroke Patients.Neuromolecular medicine · 2016Article
- Renalase attenuates hypertension, renal injury and cardiac remodelling in rats with subtotal nephrectomy.Journal of cellular and molecular medicine · 2016Article
- KALRN Rare and Common Variants and Susceptibility to Ischemic Stroke in Chinese Han Population.Neuromolecular medicine · 2015Article
- The association study on renalase polymorphism and hypertension: a meta-analysis.International journal of clinical and experimental medicine · 2015Article
- Renalase: its role as a cytokine, and an update on its association with type 1 diabetes and ischemic stroke.Current opinion in nephrology and hypertension · 2014Review
- Renalase, a new secretory enzyme: Its role in hypertensive-ischemic cardiovascular diseases.Medical science monitor : international medical journal of experimental and clinical research · 2014Review
- Association of imaging classification of intracranial cerebral atherosclerotic vascular stenosis in ischemic stroke and renalase gene polymorphisms.Journal of molecular neuroscience : MN · 2014Article
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ischemic stroke is a leading cause of death and adult disability worldwide. Recent research suggests that renalase is strongly associated with heart disease and hypertension and may play a role in ischemic stroke. In this study, we investigate the genetic association between renalase and ischemic stroke in a northern Chinese Han population. We genotyped single-nucleotide polymorphisms of the renalase gene in 507 ischemic stroke patients and 503 gender-matched controls from a northern Chinese Han population, and we classified these case samples in depth by complications with diabetes or hypertension and by ischemic stroke subtypes. We undertook allele, genotype, and haplotype association studies in all the cases and in the subgroups, as well as multiple factor analysis by logistic regression. rs10887800 and rs2576178 were significantly associated with ischemic stroke with hypertension by logistic regression (p = 0.041 and p = 0.038, respectively). The recessive model showed a strong association of rs2296545 with ischemic stroke patients in hypertension subgroups (OR = 1.927, 95 % CI = 1.012-3.669, p = 0.046). The renalase gene is closely related to ischemic stroke in this northern Chinese Han population, suggesting that renalase may be mechanistically involved in stroke pathology.
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