ArticleBrain imaging and behavior2013
Impact of body mass index on neuronal fiber bundle lengths among healthy older adults.
Article in Brain imaging and behavior, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 37 citations in OpenAlex.
- Association between the atherogenic index of plasma and cognitive impairment.Scientific reports · 2026Article
- The Glymphatic System and Obesity: A Diffusion Tensor Imaging ALPS Study.Biomedicines · 2025Article
- Radiomic and proteomic signatures of body mass index on brain ageing and Alzheimer's-like patterns of brain atrophy.EBioMedicine · 2025Article
- Social network size, empathy, and white matter: A diffusion tensor imaging (DTI) study.Cognitive, affective & behavioral neuroscience · 2025Article
- Review
- Poor Cognitive Agility Conservation in Obese Aging People.Biomedicines · 2023Article
- Understanding the Heterogeneity of Obesity and the Relationship to the Brain-Gut Axis.Nutrients · 2020Article
- Behavioral inhibition corresponds to white matter fiber bundle integrity in older adults.Brain imaging and behavior · 2019Article
- White matter fiber bundle lengths are shorter in cART naive HIV: an analysis of quantitative diffusion tractography in South Africa.Brain imaging and behavior · 2018Article
- Independent and Differential Effects of Obesity and Hypertension on Cognitive and Functional Abilities.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2018Article
- White matter microstructure and cognitive decline in metabolic syndrome: a review of diffusion tensor imaging.Metabolism: clinical and experimental · 2018Review
- Differential associations between systemic markers of disease and white matter tissue health in middle-aged and older adults.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2017Article
- Cognitive reserve moderates the relationship between neuropsychological performance and white matter fiber bundle length in healthy older adults.Brain imaging and behavior · 2017Article
- Article
- Obesity associated with increased brain age from midlife.Neurobiology of aging · 2016Article
- Posttraumatic Stress Disorder as a Catalyst for the Association Between Metabolic Syndrome and Reduced Cortical Thickness.Biological psychiatry · 2016Article
- APPLICATION OF A NOVEL QUANTITATIVE TRACTOGRAPHY-BASED ANALYSIS OF DIFFUSION TENSOR IMAGING TO EXAMINE FIBER BUNDLE LENGTH IN HUMAN CEREBRAL WHITE MATTER.Technology and innovation · 2016Article
- Article
- Neuromarkers of the common angiotensinogen polymorphism in healthy older adults: A comprehensive assessment of white matter integrity and cognition.Behavioural brain research · 2016Article
- Fiber bundle length and cognition: a length-based tractography MRI study.Brain imaging and behavior · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 5 institutions in 1 country.
Funding
Abstract
Increased body mass index (BMI) has been linked to various detrimental health outcomes, including cognitive dysfunction. Recent work investigating associations between obesity and the brain has revealed decreased white matter microstructural integrity in individuals with elevated BMI, independent of age or comorbid health conditions. However, the relationship between high BMI and white matter fiber bundle length (FBL), which represents a novel metric of microstructural brain integrity, remains unknown. The present study utilized quantitative tractography based on diffusion tensor imaging (DTI) to investigate the relationship between BMI and FBL in 72 otherwise healthy older adults (24 males, 48 females). All participants were between 51 and 85 years of age (M = 63.26, SD = 8.76). Results revealed that elevated BMI was associated with shorter FBL in the temporal lobe, independent of age (p < .01). In addition, increased age was associated with shorter frontal, temporal, and whole brain FBL (all p values < .01). These findings indicate that, while increased age is an important factor associated with reduced FBL, high BMI is uniquely associated with reduced FBL in the temporal lobe. These data offer evidence for additive adverse effects of high BMI on the brain, especially in areas already vulnerable to aging processes and age-related neurodegenerative diseases. Further research is necessary to determine the physiological mechanisms associated with the shortening of FBL in individuals with high BMI.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.