ArticleJournal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract2013
Adenocarcinoma of the esophagus in the young.
Article in Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Survival outcomes in early-onset oesophageal adenocarcinoma patients: A systematic review and meta-analyses.World journal of gastroenterology · 2024Pooled it
- Early adenocarcinoma mixed with a neuroendocrine carcinoma component arising in the gastroesophageal junction: A case report.World journal of gastrointestinal oncology · 2024Article
- Construction and verification of prognostic nomogram for early-onset esophageal cancer.Bosnian journal of basic medical sciences · 2021Article
- Is the age of diagnosis of esophageal adenocarcinoma getting younger? Analysis at a tertiary care center.Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus · 2020Article
- Clinical characteristics of young patients with early Barrett's neoplasia.World journal of gastroenterology · 2019Article
- Esophageal cancer in patients under 50: a SEER analysis.Journal of thoracic disease · 2018Article
- Young Adult Cancer: Influence of the Obesity Pandemic.Obesity (Silver Spring, Md.) · 2018Review
- Esophageal cancer in elderly patients: a population-based study.Journal of thoracic disease · 2018Article
- Clinicopathological features and prognosis of patients <45 years old with esophageal adenocarcinoma comparing to other age groups.Journal of thoracic disease · 2016Article
- Early onset esophageal adenocarcinoma: a distinct molecular entity?Oncoscience · 2016Article
- Off-pump coronary artery bypass grafting via median sternotomy in a patient with a history of esophagectomy with substernal gastric tube reconstruction: report of a case.Surgery today · 2015Article
- Face Barrett's: esophageal adenocarcinoma affects the young.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2014Article
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10 authors.
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No grant is acknowledged in the PubMed record.
Abstract
introductionPractitioners have noted a striking increase in the number of young patients under the age of 40 years old who develop esophageal adenocarcinoma. The aim of this study was to characterize the presentation, pathology and therapeutic outcome of these young patients.
methodsThe records of patients who presented to the Foregut Surgical Service at the University of Southern California with esophageal adenocarcinoma between 2000 and 2007 were retrospectively reviewed. The presentation, tumor stage and histology, therapy and outcome of the patients under the age of 40 were compared to those ≥40.
resultsOf the 374 patients reviewed, 20 (5 %) were under the age of 40. There were two patients in their second and 18 in their third decade of life. The youngest patient was 25 years old. A history of gastroesophageal reflux disease or Barrett's esophagus was less common in patients <40 than in those ≥40; 15 and 5 % compared to 61 and 46 %. Similarly, patients <40 had a significantly longer time interval between the onset of symptoms and the diagnosis of their cancer than those ≥40; 4.5 vs. 2 months, p = 0.04. They also had a higher prevalence of stage IV disease (30 vs. 6 %, p = 0.0003), a shorter time to recurrence (9.5 vs.19 month, p = 0.002), and a poorer median survival (17 vs. 43 month, p = 0.04).
conclusionEsophageal adenocarcinoma in patients <40 years old commonly presents with an advanced stage of the disease and an associated poor survival. This is likely due to a low index of suspicion that dysphagia seen in younger patients is due to a malignancy.
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