ArticleAmerican journal of physiology. Heart and circulatory physiology2013
Neuronal nitric oxide synthase expression is lower in areas of the nucleus tractus solitarius excited by skeletal muscle reflexes in hypertensive rats.
Article in American journal of physiology. Heart and circulatory physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 22 citations in OpenAlex.
- Blunted pressor response to peripheral sensory afferent nerve stimulation in intracerebroventricular-streptozotocin injected rats.Autonomic neuroscience : basic & clinical · 2025Article
- Abnormal cardiovascular control during exercise: Role of insulin resistance in the brain.Autonomic neuroscience : basic & clinical · 2025Review
- Inhibitory effect of exercise on elevated blood pressure and fetal growth restriction during pregnancy in Dahl salt-sensitive rats.Physiological reports · 2025Article
- Blockade of insulin receptor signaling in the medullary cardiovascular centers impairs open-loop arterial baroreflex function via attenuated neural arc in healthy male rats.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
- Recent advances in exercise pressor reflex function in health and disease.Autonomic neuroscience : basic & clinical · 2020Review
- The Pressor Response to Concurrent Stimulation of the Mesencephalic Locomotor Region and Peripheral Sensory Afferents Is Attenuated in Normotensive but Not Hypertensive Rats.Frontiers in physiology · 2019Article
- Antihypertensive Treatment Fails to Control Blood Pressure During Exercise.Hypertension (Dallas, Tex. : 1979) · 2018Article
- Implicating the potential role of orexin in hypertension.Naunyn-Schmiedeberg's archives of pharmacology · 2017Review
- Intrathecal fentanyl abolishes the exaggerated blood pressure response to cycling in hypertensive men.The Journal of physiology · 2016Article
- Exaggerated sympathetic and cardiovascular responses to stimulation of the mesencephalic locomotor region in spontaneously hypertensive rats.American journal of physiology. Heart and circulatory physiology · 2016Article
- Exercise, the Brain, and Hypertension.Current hypertension reports · 2015Review
- Dynamic exercise training prevents exercise pressor reflex overactivity in spontaneously hypertensive rats.American journal of physiology. Heart and circulatory physiology · 2015Article
- Muscle mechanoreflex overactivity in hypertension: a role for centrally-derived nitric oxide.Autonomic neuroscience : basic & clinical · 2015Review
- Lack of neuronal nitric oxide synthase results in attention deficit hyperactivity disorder-like behaviors in mice.Behavioral neuroscience · 2015Article
- Autonomic dysfunction in muscular dystrophy: a theoretical framework for muscle reflex involvement.Frontiers in physiology · 2014Review
- Treatment of muscle mechanoreflex dysfunction in hypertension: effects of L-arginine dialysis in the nucleus tractus solitarii.Experimental physiology · 2013Article
- GABAB receptor gene transfer into the nucleus tractus solitarii induces chronic blood pressure elevation in normotensive rats.Circulation journal : official journal of the Japanese Circulation Society · 2013Article
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6 authors at 1 institution in 1 country.
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Abstract
The functions of the skeletal muscle exercise pressor reflex (EPR) and its mechanically sensitive component are augmented in hypertension producing exaggerated increases in blood pressure during exercise. Afferent information from the EPR is processed in the nucleus tractus solitarius (NTS). Within the NT, nitric oxide (NO), produced via L-arginine oxidation by neuronal nitric oxide synthase (nNOS), buffers the pressor response to EPR activation. Therefore, EPR overactivity may manifest as a decrease in NO production due to reductions in nNOS. We hypothesized that nNOS protein expression is lower in the NTS of spontaneously hypertensive (SHR) compared with normotensive Wistar-Kyoto (WKY) rats. Further, we examined whether nNOS is expressed with FOS, a marker of neuronal excitation induced by EPR activation. The EPR and mechanoreflex were intermittently activated for 1 h via hindlimb static contraction or stretch, respectively. These maneuvers produced significantly greater pressor responses in SHR during the first 25 min of stimulation. Within the NTS, nNOS expression was lower from -14.9 to -13.4 bregma in SHR compared with WKY. For example, at -14.5 bregma the number of NTS nNOS-positive cells in SHR (13 ± 1) was significantly less than WKY (23 ± 2). However, the number of FOS-positive cells after muscle contraction in this area was not different (WKY = 82 ± 18; SHR = 75 ± 8). In both groups, FOS-expressing neurons were located within the same areas of the NTS as neurons containing nNOS. These findings demonstrate that nNOS protein expression is lower within NTS areas excited by skeletal muscle reflexes in hypertensive rats.
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