ArticleJournal of molecular neuroscience : MN2013
Association between SLC1A1 gene and early-onset OCD in the Han Chinese population: a case-control study.
Article in Journal of molecular neuroscience : MN, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 25 citations in OpenAlex.
- Solute carrier family 1 member 1 in renal interstitial fibrosis: evaluating its influence on glutamate uptake and extracellular ion levels.Frontiers in medicine · 2025Article
- Hereditary Patterns and Genetic Associations in Obsessive-Compulsive Disorder (OCD): Neuropsychiatric Insights, Genetic Influences, and Treatment Perspectives.Current gene therapy · 2025Review
- Association Between theNeuropsychiatric disease and treatment · 2021Article
- Genetics of obsessive-compulsive disorder.Indian journal of psychiatry · 2019Review
- Rodent models of obsessive compulsive disorder: Evaluating validity to interpret emerging neurobiology.Neuroscience · 2017Review
- Glutamate Genetics in Obsessive-Compulsive Disorder: A Review.Journal of the Canadian Academy of Child and Adolescent Psychiatry = Journal de l'Academie canadienne de psychiatrie de l'enfant et de l'adolescent · 2017Article
- The importance of the excitatory amino acid transporter 3 (EAAT3).Neurochemistry international · 2016Review
- Learning From Animal Models of Obsessive-Compulsive Disorder.Biological psychiatry · 2016Review
- An association study between DLGAP1 rs11081062 and EFNA5 rs26728 polymorphisms with obsessive-compulsive disorder in a Chinese Han population.Neuropsychiatric disease and treatment · 2015Article
- The neurobiological link between OCD and ADHD.Attention deficit and hyperactivity disorders · 2014Review
- Obsessive-compulsive disorder: an integrative genetic and neurobiological perspective.Nature reviews. Neuroscience · 2014Review
- Strong association ofAsian journal of andrologyArticle
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Obsessive-compulsive disorder (OCD) is a common and severe mental illness, and its etiology still remains unknown. The glutamate transporter gene solute carrier family 1, member 1 was previously tested as a promising candidate for OCD by several research groups. However, subsequent studies were not consistent. OCD is a heterogeneous disease. Early-onset OCD is a demographically and clinically distinct subtype of OCD and may be a more homogeneous subtype. Gender-matched 244 early-onset OCD patients, 244 late-onset OCD patients, and 244 healthy controls were genotyped with four SNPs (rs10491734, rs2228622, rs301430, and rs301443) through TaqMan SNP genotyping assays. There were statistical differences in allele and genotype frequencies of rs10491734 in early-onset OCD patients compared to late-onset OCD or control subjects. The haplotype analysis showed that the four-locus haplotype (A-A-C-C and A-G-C-C) were associated with early onset obsessive-compulsive disorder after Bonferroni correction. The present study provided suggestive evidence that the rs10491734 was significantly associated with early-onset OCD in the Han Chinese population. However, these findings need further replication.
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