ArticleGenome biology and evolution2013
Functional and evolutionary analysis of the genome of an obligate fungal symbiont.
Article in Genome biology and evolution, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
34 citing papers in PubMed, 68 citations in OpenAlex.
- Multi-Omics Profiling of the Scaphoideus titanus Yeast-Like Symbiont Guides the Bioinformatic Discovery of Related Fungal Symbioses in Insects.Environmental microbiology · 2026Article
- Genome diversification of symbiotic fungi in beetle-fungus mutualistic symbioses.The ISME journal · 2026Article
- Transcriptome Analysis of the Fat Body of the Maize Pest Delphacodes kuscheli (Hemiptera: Delphacidae) Reveals Essential Roles of Fungal Endosymbionts.Microbial ecology · 2025Article
- Harnessing Nutritional Niches to Explore Fungus-Animal Symbioses.Ecology letters · 2025Review
- An endosymbiotic origin of the crimson pigment from the lac insect.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Environmental yeasts differentially impact the development and oviposition behavior of the Asian tiger mosquito Aedes albopictus.Microbiome · 2025Article
- Endosymbioses Have Shaped the Evolution of Biological Diversity and Complexity Time and Time Again.Genome biology and evolution · 2024Review
- Highly Reduced Complementary Genomes of Dual Bacterial Symbionts in the Mulberry Psyllid Anomoneura mori.Microbes and environments · 2024Article
- Patterns of asexual reproduction of the soybean aphid,Frontiers in microbiology · 2023Article
- Microbiome Analysis of the Bamboo AphidInsects · 2022Article
- The Role of Insect Symbiotic Bacteria in Metabolizing Phytochemicals and Agrochemicals.Insects · 2022Review
- Metatranscriptomic Assessment of the Microbial Community Associated With the Flavescence dorée Phytoplasma Insect VectorFrontiers in microbiology · 2022Article
- SymbiQuant: A Machine Learning Object Detection Tool for Polyploid Independent Estimates of Endosymbiont Population Size.Frontiers in microbiology · 2022Article
- Fungal biodiversity and conservation mycology in light of new technology, big data, and changing attitudes.Current biology : CB · 2021Review
- Diversity and Functions of Yeast Communities Associated with Insects.Microorganisms · 2021Review
- Comparative genomics reveals a core gene toolbox for lifestyle transitions in Hypocreales fungi.Environmental microbiology · 2021Article
- The Ubiquity and Development-Related Abundance Dynamics ofMicroorganisms · 2021Article
- Article
- Rediscovering a Forgotten System of Symbiosis: Historical Perspective and Future Potential.Genes · 2020Review
- Dynamics of Insect-Microbiome Interaction Influence Host and Microbial Symbiont.Frontiers in microbiology · 2020Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nutritional symbionts of insects include some of the most bizarre genomes studied to date, with extremely reduced size, biased base composition, and limited metabolic abilities. A monophyletic group of aphids within the subfamily Cerataphidinae have lost the bacterial symbiont common to all other Aphididae (Buchnera aphidicola), which have been replaced by a eukaryotic one, the yeast-like symbiont (YLS). As symbionts are expected to experience reduced effective population size (Ne) and largely clonal life cycles, we used this system as a model to test the hypothesis that chronically high levels of genetic drift will result in an increase in size of a eukaryotic genome. We sequenced the genome of the YLS of the aphid Cerataphis brasiliensis and observed elevated rates of protein sequence evolution and intron proliferation in YLS orthologs relative to those of its closest-sequenced relative, consistent with predictions. A moderate amount of repetitive DNA was found along with evidence of directed mutation to prevent proliferation of repetitive elements. Despite increased intron numbers, the overall genome structure appears not to have undergone massive expansion and is around 25 Mb in size. Compared with Buchnera, the YLS appears to have a much broader metabolic repertoire, though many gene families have been reduced in the YLS relative to related fungi. The patterns observed in the YLS genome suggest that its symbiotic lifestyle is permissive to intron proliferation and accelerated sequence evolution, though other factors appear to limit its overall genome expansion.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.