Evidence map›Paper›PMID 23563753›Full record

ArticleHeart and vessels2014

Takotsubo cardiomyopathy in siblings.

Masayasu Ikutomi, Masao Yamasaki, Masashiro Matsusita, Yuji Watari, Hiroyuki Arashi, Goro Endo, Jun-ichi Yamaguchi, Satoshi Ohnishi

Registry-linked trialAbstract readCase ReportsVideo-Audio Media
PubMed Publisher
In one paragraph

Article in Heart and vessels, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04513054 (Is There a Genetic Predisposition for Acute Stress-induced), which is not on this map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04513054 narecruitingnot on this mapstarted 2019, after this paper: background citation

Is There a Genetic Predisposition for Acute Stress-induced (Takotsubo) Cardiomyopathy: The GENETIC Study

TypeinterventionalSponsorUniversity of AberdeenRan2019 to 2028Enrolled700ConditionsTakotsubo CardiomyopathyArmsBlood collection for genetic analysis
3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Genetic and Epigenetic Factors of Takotsubo Syndrome: A Systematic Review.International journal of molecular sciences · 2021
    Pooled it
  2. A Genome-Wide Association Study of Takotsubo Syndrome.JACC. Basic to translational science · 2026
    Article
  3. Review
  4. Review
  5. Molecular Mechanisms of Takotsubo Syndrome.International journal of molecular sciences · 2022
    Review
  6. Review
  7. Review
  8. Article
  9. The role of multimodality imaging in takotsubo cardiomyopathy.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2019
    Review
  10. Takotsubo twins.BMJ case reports · 2019
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Takotsubo syndrome.Indian heart journal
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Masayasu IkutomiNTT Medical Center, 5-9-22 Higashi-Gotanda, Shinagawa-ku, Tokyo, 141-8625, Japan, mikutomi@gmail.com.
Masao Yamasaki
Masashiro Matsusita
Yuji Watari
Hiroyuki Arashi
Goro Endo
Jun-ichi Yamaguchi
Satoshi Ohnishi

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report the case of apical ballooning syndrome (ABS) in a female sibling. A 64-year-old woman was admitted to our hospital with sudden-onset chest pain. Cardiac enzymes were mildly elevated and an electrocardiogram showed broad ST-T changes. Emergency coronary angiography revealed no culprit lesion and left ventriculography demonstrated focal akinesis of the apical wall, which was consistent with ABS. Myocardial functional sympathetic innervations assessed using [(123)I]metaiodobenzylguanidine was severely impaired in the apical region. Her clinical symptoms and cardiac dysfunction recovered spontaneously. Just 1 year prior to our patient's cardiac event, her elder sister had the same symptoms and was also diagnosed with ABS. Both sisters were postmenopausal. The familial case of ABS is exceedingly rare, but these cases suggest a possible genetic etiology.

Indexed as

SiblingsAgedFemaleGenetic Predisposition to DiseaseHumansMiddle AgedPedigreePhenotypePostmenopauseRadionuclide VentriculographyRisk FactorsTakotsubo CardiomyopathyTomography, Emission-Computed, Single-Photon

Identifiers

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.