ReviewHandbook of experimental pharmacology2013
The involvement of sphingolipids in chronic obstructive pulmonary diseases.
Review in Handbook of experimental pharmacology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 28 citations in OpenAlex.
- Linking Lipid Metabolism and Immune Function: New Insights into Chronic Respiratory Diseases.Pathophysiology : the official journal of the International Society for Pathophysiology · 2025Review
- Double-side role of short chain fatty acids on host health via the gut-organ axes.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2024Review
- Role of Short-Chain Fatty Acids Produced by Gut Microbiota in Innate Lung Immunity and Pathogenesis of the Heterogeneous Course of Chronic Obstructive Pulmonary Disease.International journal of molecular sciences · 2022Review
- Review
- Multiplex-Heterogeneous Network-Based Capturing Potential SNP "Switches" of Pathways Associating With Diverse Disease Characteristics of Asthma.Frontiers in cell and developmental biology · 2021Article
- Serum Sphingolipids Aiding the Diagnosis of Adult HIV-Negative Patients withFrontiers in cellular and infection microbiology · 2021Article
- Metabolomics and transcriptomics pathway approach reveals outcome-specific perturbations in COPD.Scientific reports · 2018Article
- Article
- Neutrophil elastase increases airway ceramide levels via upregulation of serine palmitoyltransferase.American journal of physiology. Lung cellular and molecular physiology · 2018Article
- Myriocin treatment of CF lung infection and inflammation: complex analyses for enigmatic lipids.Naunyn-Schmiedeberg's archives of pharmacology · 2017Article
- Metabolomic similarities between bronchoalveolar lavage fluid and plasma in humans and mice.Scientific reports · 2017Observational
- Ceramide Signaling and Metabolism in Pathophysiological States of the Lung.Annual review of physiology · 2016Review
- Aberrant ORM (yeast)-like protein isoform 3 (ORMDL3) expression dysregulates ceramide homeostasis in cells and ceramide exacerbates allergic asthma in mice.The Journal of allergy and clinical immunology · 2015Article
- Plasma sphingolipids associated with chronic obstructive pulmonary disease phenotypes.American journal of respiratory and critical care medicine · 2015Article
- Role of Sphingolipids in the Pathobiology of Lung Inflammation.Mediators of inflammation · 2015Review
- Plasma sphingomyelin and longitudinal change in percent emphysema on CT. The MESA lung study.Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Chronic obstructive pulmonary disease (COPD) includes a spectrum of conditions that have in common varying degrees of airflow obstruction, such as chronic bronchitis and emphysema. There is an increasing evidence of involvement of sphingolipids as key molecular mediators or biomarkers of disease in emphysema, chronic bronchitis, and more recently in asthma, another disease characterized by (reversible) airflow obstruction. Given the recognized central role of oxidative stress and inflammatory stimuli along with involvement of immune responses, apoptosis, and tissue remodeling in the development of chronic obstructive lung diseases, it is not surprising that sphingolipids have been shown to play important role in their pathobiology. In particular the pro-apoptotic effects of ceramide were suspected as events in the lung destruction that occurs as a result of apoptotic loss of structural cells comprising the alveolar walls, such as microvascular endothelial cells and alveolar epithelial cells. In addition, the role of ceramide was investigated in models of larger airway epithelial cell stress responses to cigarette smoke, in the context of ensuing airway remodeling and inflammation. This chapter discusses current evidence of sphingolipid perturbations in experimental models of COPD and relevant links to human disease based on translational and epidemiological data.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.