ArticleNature genetics2013
Genome-wide SNP and CNV analysis identifies common and low-frequency variants associated with severe early-onset obesity.
Article in Nature genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 174 papers, 9 of them syntheses that pooled it.
What it found
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Who cites it
174 citing papers in PubMed, 9 syntheses or guidelines pooled it, 326 citations in OpenAlex.
- Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci.Molecular psychiatry · 2020Pooled it
- GWAS on longitudinal growth traits reveals different genetic factors influencing infant, child, and adult BMI.Science advances · 2019Pooled it
- CNV-association meta-analysis in 191,161 European adults reveals new loci associated with anthropometric traits.Nature communications · 2017Pooled it
- Genome-wide association meta-analysis of 78,308 individuals identifies new loci and genes influencing human intelligence.Nature genetics · 2017Pooled it
- Mendelian randomisation analysis strongly implicates adiposity with risk of developing colorectal cancer.British journal of cancer · 2016Pooled it
- New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk.Nature communications · 2016Pooled it
- Contribution of common non-synonymous variants in PCSK1 to body mass index variation and risk of obesity: a systematic review and meta-analysis with evidence from up to 331 175 individuals.Human molecular genetics · 2015Pooled it
- A genome-wide association study of body mass index across early life and childhood.International journal of epidemiology · 2015Pooled it
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- Leptin-Mediated Changes in the Human Metabolome.The Journal of clinical endocrinology and metabolism · 2020Trial
- Genome-wide burden and association analyses implicate copy number variations in asthma risk among children and young adults from Latin America.Scientific reports · 2018Trial
- Leptin Receptor Gene Variant rs11804091 Is Associated with BMI and Insulin Resistance in Spanish Female Obese Children: A Case-Control Study.International journal of molecular sciences · 2017Trial
- Role of Oxytocin in Obesity.Current diabetes reports · 2026Review
- The genetics of fibromyalgia and its relationships to psychiatric and medical traits.Nature communications · 2026Article
- Palmitoylation calibrates mitochondrial transport of insulin across the endothelium in insulin resistance.bioRxiv : the preprint server for biology · 2026Article
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- Shared genetic architecture between obesity and psychiatric disorders reveals comorbid etiology and therapeutic targets.Life medicine · 2026Article
- PACS1 syndrome mutation disrupts dynein-mediated cargo transport via HDAC6 and BICD2.Communications biology · 2026Article
- Copy Number Variation Analysis.Methods in molecular biology (Clifton, N.J.) · 2026Article
114 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
14 authors at 3 institutions in 1 country.
Funding
Abstract
Common and rare variants associated with body mass index (BMI) and obesity account for <5% of the variance in BMI. We performed SNP and copy number variation (CNV) association analyses in 1,509 children with obesity at the extreme tail (>3 s.d. from the mean) of the BMI distribution and 5,380 controls. Evaluation of 29 SNPs (P < 1 × 10(-5)) in an additional 971 severely obese children and 1,990 controls identified 4 new loci associated with severe obesity (LEPR, PRKCH, PACS1 and RMST). A previously reported 43-kb deletion at the NEGR1 locus was significantly associated with severe obesity (P = 6.6 × 10(-7)). However, this signal was entirely driven by a flanking 8-kb deletion; absence of this deletion increased risk for obesity (P = 6.1 × 10(-11)). We found a significant burden of rare, single CNVs in severely obese cases (P < 0.0001). Integrative gene network pathway analysis of rare deletions indicated enrichment of genes affecting G protein-coupled receptors (GPCRs) involved in the neuronal regulation of energy homeostasis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.