ArticleBioengineered
Increasing the production yield of recombinant protein in transgenic seeds by expanding the deposition space within the intracellular compartment.
Article in Bioengineered. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 26 citations in OpenAlex.
- Subcellular localization of C-term-oleosin fused to β-casein reveals unexpected cytoplasmic accumulation in vacuole-targeted arabidopsis seeds.Frontiers in plant science · 2026Article
- Influence on Accumulation Levels and Subcellular Localization of Prolamins by Fusion with the Functional Peptide in Transgenic Rice Seeds.Molecular biotechnology · 2023Article
- Targeted genome editing of plants and plant cells for biomanufacturing.Transgenic research · 2021Review
- Compensatory rebalancing of rice prolamins by production of recombinant prolamin/bioactive peptide fusion proteins within ER-derived protein bodies.Plant cell reports · 2018Article
- Vacuolar deposition of recombinant proteins in plant vegetative organs as a strategy to increase yields.Bioengineered · 2017Review
- Proteome rebalancing in transgenic Camelina occurs within the enlarged proteome induced by β-carotene accumulation and storage protein suppression.Transgenic research · 2017Article
- Deposition mode of transforming growth factor-β expressed in transgenic rice seed.Plant cell reports · 2016Article
- Metabolic Regulation of Carotenoid-Enriched Golden Rice Line.Frontiers in plant science · 2016Article
- The increasing value of plant-made proteins.Current opinion in biotechnology · 2015Review
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Seeds must maintain a constant level of nitrogen in order to germinate. When recombinant proteins are produced while endogenous seed protein expression is suppressed, the production levels of the foreign proteins increase to compensate for the decreased synthesis of endogenous proteins. Thus, exchanging the production of endogenous seed proteins for that of foreign proteins is a promising approach to increase the yield of foreign recombinant proteins. Providing a space for the deposition of recombinant protein in the intracellular compartment is critical, at this would lessen any competition in this region between the endogenous seed proteins and the introduced foreign protein. The production yields of several recombinant proteins have been greatly increased by this strategy.
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