ArticleEukaryotic cell2013
Pathway of glycine betaine biosynthesis in Aspergillus fumigatus.
Article in Eukaryotic cell, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 41 citations in OpenAlex.
- Comparative genomics reveals substantial divergence in metal sensitive and metal tolerant isolates of the ericoid mycorrhizal fungus Oidiodendron maius.Mycorrhiza · 2025Article
- Engineering stress resistance: advances in glycine betaine production for sustainable agriculture.Crop health · 2025Review
- Characterization of a Drought-Induced Betaine Aldehyde Dehydrogenase GenePlants (Basel, Switzerland) · 2024Article
- Reconstruction of a genome-scale metabolic model and in-silico flux analysis of Aspergillus tubingensis: a non-mycotoxinogenic citric acid-producing fungus.Biotechnology for biofuels and bioproducts · 2024Article
- Light effects on Lasiodiplodia theobromae metabolome cultured in vitro.Metabolomics : Official journal of the Metabolomic Society · 2023Article
- Degradation of betaine aldehyde dehydrogenase transgenic maize BZ-136 straw and its effects on soil nutrients and fungal community.Frontiers in microbiology · 2023Article
- RNA-Seq Based Transcriptome Analysis ofJournal of fungi (Basel, Switzerland) · 2022Article
- Isolation, Characterization, and Metabolic Profiling ofMycobiology · 2022Article
- Reconstitution of biosynthetic pathway for mushroom-derived cyathane diterpenes in yeast and generation of new "non-natural" analogues.Acta pharmaceutica Sinica. B · 2021Article
- Article
- Genomic Blueprint of Glycine Betaine Metabolism in Coral Metaorganisms and Their Contribution to Reef Nitrogen Budgets.iScience · 2020Article
- Sugar Beet (International journal of molecular sciences · 2020Article
- Nitrogen source-dependent inhibition of yeast growth by glycine and its N-methylated derivatives.Antonie van Leeuwenhoek · 2020Article
- Article
- Biosynthesis and uptake of glycine betaine as cold-stress response to low temperature in fish pathogen Vibrio anguillarum.Journal of microbiology (Seoul, Korea) · 2017Article
- RNAseq analysis of Aspergillus fumigatus in blood reveals a just wait and see resting stage behavior.BMC genomics · 2015Article
- Dimethylglycine provides salt and temperature stress protection to Bacillus subtilis.Applied and environmental microbiology · 2014Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The choline oxidase (CHOA) and betaine aldehyde dehydrogenase (BADH) genes identified in Aspergillus fumigatus are present as a cluster specific for fungal genomes. Biochemical and molecular analyses of this cluster showed that it has very specific biochemical and functional features that make it unique and different from its plant and bacterial homologs. A. fumigatus ChoAp catalyzed the oxidation of choline to glycine betaine with betaine aldehyde as an intermediate and reduced molecular oxygen to hydrogen peroxide using FAD as a cofactor. A. fumigatus Badhp oxidized betaine aldehyde to glycine betaine with reduction of NAD(+) to NADH. Analysis of the AfchoAΔ::HPH and AfbadAΔ::HPH single mutants and the AfchoAΔAfbadAΔ::HPH double mutant showed that AfChoAp is essential for the use of choline as the sole nitrogen, carbon, or carbon and nitrogen source during the germination process. AfChoAp and AfBadAp were localized in the cytosol of germinating conidia and mycelia but were absent from resting conidia. Characterization of the mutant phenotypes showed that glycine betaine in A. fumigatus functions exclusively as a metabolic intermediate in the catabolism of choline and not as a stress protectant. This study in A. fumigatus is the first molecular, cellular, and biochemical characterization of the glycine betaine biosynthetic pathway in the fungal kingdom.
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