ArticleBiosensors & bioelectronics2013
Glycosylated aniline polymer sensor: amine to imine conversion on protein-carbohydrate binding.
Article in Biosensors & bioelectronics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 39 citations in OpenAlex.
- A Critical Review on Covalent Organic Frameworks as Emerging Electrocatalysts for Electrochemical Glucose Sensing.Chemistry, an Asian journal · 2026Review
- Tuning Surface Properties via Plasma Treatments for the Improved Capture of MicroRNA Biomarkers.Materials (Basel, Switzerland) · 2022Article
- Glycoprotein- and Lectin-Based Approaches for Detection of Pathogens.Pathogens (Basel, Switzerland) · 2020Review
- Self-regulation in chemical and bio-engineering materials for intelligent systems.CAAI Transactions on Intelligence Technology · 2018Article
- Acoustofluidic bacteria separation.Journal of micromechanics and microengineering : structures, devices, and systems · 2017Article
- Recent Progress in Electrochemical Biosensors for Glycoproteins.Sensors (Basel, Switzerland) · 2016Review
- Glycan and lectin biosensors.Essays in biochemistry · 2016Review
- Recent Progress in Lectin-Based Biosensors.Materials (Basel, Switzerland) · 2015Review
- An ultrasensitive impedimetric glycan biosensor with controlled glycan density for detection of lectins and influenza hemagglutinins.Chemical communications (Cambridge, England) · 2015Article
- Are glycan biosensors an alternative to glycan microarrays?Analytical methods : advancing methods and applications · 2014Article
- Square-wave voltammetry assays for glycoproteins on nanoporous gold.Journal of electroanalytical chemistry (Lausanne, Switzerland) · 2014Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
In this report, functionalized mannosylated aniline polymer (manno-PANI) was investigated as an electrochemical platform to study carbohydrate-protein interactions by exploiting the conductivity change of manno-PANI when the specific lectin binding occurs. A systematic study was performed to characterize the interconversion of polyaniline content (from amine to imine) in manno-PANI by UV-vis spectroscopy during its binding with concanavalin A (Con A). Both X-ray photoelectron spectrometry (XPS) and UV-vis results suggest that Con A binding with the manno-PANI film triggers the switching of amine functionalities in the polyaniline backbone, converting them to imine forms. Electrochemical impedance spectroscopy (EIS) was used to quantify the specific interactions between Con A and mannose by measuring the impedance change of manno-PANI film for the detection of Con A. A linear relationship between the impedance and Con A concentration was obtained, and the detection limit reaches to 0.12 nM Con A in a buffer solution (pH=7.4), whereas the addition of nonspecific control lectins to the same manno-PANI film gave very little impedance variations. Stability characterization of the manno-PANI film over 20 weeks shows a maximum drift of only 3% from the original signal. Thus, the uniquely constructed carbohydrate-PANI hybrid is a promising new carbohydrate recognition moiety for studying carbohydrate-protein interactions, presumably leading to a new electrochemical method for characterization of carbohydrate-protein interactions and carbohydrate-mediated intercellular recognitions.
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Registered trials
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