ArticlePediatric research2013
Intra-amniotic LPS amplifies hyperoxia-induced airway hyperreactivity in neonatal rats.
Article in Pediatric research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 18 citations in OpenAlex.
- Caffeine prevents airway hyperreactivity in a neonatal mouse model of continuous positive airway pressure.Pediatric research · 2026Article
- Identification of a FGF18-expressing alveolar myofibroblast that is developmentally cleared during alveologenesis.Development (Cambridge, England) · 2020Article
- Rodent models of respiratory control and respiratory system development-Clinical significance.Respiratory physiology & neurobiology · 2019Review
- Hyperoxia-induced lung structure-function relation, vessel rarefaction, and cardiac hypertrophy in an infant rat model.Journal of translational medicine · 2019Article
- Human amnion cells reverse acute and chronic pulmonary damage in experimental neonatal lung injury.Stem cell research & therapy · 2017Article
- Human amnion epithelial cells rescue cell death via immunomodulation of microglia in a mouse model of perinatal brain injury.Stem cell research & therapy · 2017Article
- Effects of antenatal lipopolysaccharide and postnatal hyperoxia on airway reactivity and remodeling in a neonatal mouse model.Pediatric research · 2016Article
- The Effect of Continuous Positive Airway Pressure in a Mouse Model of Hyperoxic Neonatal Lung Injury.Neonatology · 2016Article
- Perinatal oxygen in the developing lung.Canadian journal of physiology and pharmacology · 2015Review
- Article
- Repeated β2-adrenergic receptor agonist therapy attenuates the response to rescue bronchodilation in a hyperoxic newborn mouse model.Neonatology · 2014Article
- Anti-inflammatory effect of caffeine is associated with improved lung function after lipopolysaccharide-induced amnionitis.Neonatology · 2014Article
Corrections and comments
- Retraction · 2019-09-03Investigation by Company/Institution · Misconduct - Official Investigation(s) and/or Finding(s) · Misconduct by Author · · Erin Potts-Kant has finding of misconduct
- Commented on by
- Retracted
Authors and funding
6 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWe previously showed that intra-amniotic lipopolysaccharide (LPS) amplifies alveolar hypoplasia induced by postnatal hyperoxia. We determined whether the priming effect of intra-amniotic LPS amplifies hyperoxia-induced airway hyperreactivity (AHR).
methodsLPS or normal saline was injected into the amniotic cavities of pregnant rats at the 20th day of gestation. After birth, rat pups were exposed to 60% O₂ or air for 14 d. On postnatal day 14, rat pups underwent forced oscillometry, which included a challenge with nebulized methacholine, and the lungs were harvested for morphological studies.
resultsHyperoxia significantly increased airway reactivity and decreased compliance. Intra-amniotic LPS further increased hyperoxia-induced AHR but did not further impair respiratory system compliance. Hyperoxia-induced changes in lung parenchymal and small airway morphology were not further altered by intra-amniotic LPS. However, combined exposure to intra-amniotic LPS and hyperoxia increased the proportion of degranulating mast cells in the hilar airways.
conclusionIntra-amniotic LPS amplified postnatal hyperoxia-induced AHR. This was associated with increased airway mast cell degranulation, which has previously been linked with hyperoxia-induced AHR. There were no morphologic changes of parenchyma or airways that would account for the LPS augmentation of hyperoxia-induced AHR.
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