Evidence map›Paper›PMID 23563156›Full record

ReviewRespiratory physiology & neurobiology2013

Genotype-phenotype interactions in pediatric obstructive sleep apnea.

Leila Kheirandish-Gozal, David Gozal

Open access · greenAbstract readReview
In one paragraph

Review in Respiratory physiology & neurobiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
5.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 57 citations in OpenAlex.

  1. Review
  2. Frontiers in genetics · 2023
    Article
  3. Article
  4. Article
  5. Use of facial stereophotogrammetry as a screening tool for pediatric obstructive sleep apnea by dental specialists.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2022
    Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Review
  13. Article
  14. Review
  15. Review
  16. Adenoid Vegetation in Children with Allergic Rhinitis.Turkish archives of otorhinolaryngology · 2015
    Article
  17. Article
  18. Article
  19. Clinical challenges to ventilatory control.Respiratory physiology & neurobiology · 2013
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Leila Kheirandish-GozalSections of Pediatric Sleep Medicine and Pediatric Pulmonology, Department of Pediatrics, Comer Children's Hospital, Pritzker School of Medicine, The University of Chicago, Chicago, IL, United States. Electronic address: lgozal@peds.bsd.uchicago.edu.
David Gozal
Comer Children's Hospital · US

Funding

NEUROCOGNITIVE FUNCTION IN SNORING CHILDRENR01HL065270 · NHLBI · UNIVERSITY OF LOUISVILLE · PI GOZAL, DAVID · 1999 to 2014
$5.0M
Oxidative stress in a murine model of sleep apneaR01HL086662 · NHLBI · UNIVERSITY OF LOUISVILLE · PI GOZAL, DAVID · 2008 to 2012
$1.9M
Validation of Urinary Biomarkers in Diagnosis of Pediatric OSAP50HL107160 · NHLBI · UNIVERSITY OF CHICAGO · PI GOZAL, DAVID · 2011 to 2012
$923k
NHLBI NIH HHS HL-086662NHLBI NIH HHS HL-107160NHLBI NIH HHS HL-65270NHLBI NIH HHS P50 HL107160NHLBI NIH HHS R01 HL065270NHLBI NIH HHS R01 HL086662
6 · The paper itself

Abstract

Pediatric sleep disordered breathing (PSDB) is not only a very frequent condition affecting 2-4% of all children, but is also associated with an increased risk for a variety of manifestations underlying end-organ injury and dysfunction that impose both immediate and potentially long-term morbidities and corresponding inherent elevations in healthcare costs. One of the major problems with the creation of valid algorithms aiming to stratify diagnostic and treatment prioritization lies in our current inability to predict and identify those children who are most at-risk for PSDB-induced adverse consequences. Thus, improved our understanding of the mechanisms governing phenotype variance in PSDB is essential. Here, we examine some of the potential underpinnings of phenotypic variability in PSDB, and further propose a conceptual framework aimed at facilitating the process of advancing knowledge in this frequent disorder.

Indexed as

GenotypePhenotypeChildGenetic VariationHumansSleep Apnea, ObstructiveAdenotonsillar hypertrophyEpigeneticsGenotype–phenotype interactionsIntermittent hypoxiaObstructive sleep apnea syndromePediatric sleep disordered breathingSleep fragmentationUpper airway

Identifiers

PMID23563156
PMCPMC3751986
OpenAlexW2061392402

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.