ArticleHuman molecular genetics2013
Evolutionarily conserved long intergenic non-coding RNAs in the eye.
Article in Human molecular genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 43 citations in OpenAlex.
- Retina-specific long non-coding RNAs associated with inherited retinal disease genes.Cellular and molecular life sciences : CMLS · 2026Article
- RNA dysfunction in age-related macular degeneration: the role of U1 snRNP complex and neurodegenerative diseases.International journal of retina and vitreous · 2025Review
- Identification and characterization of key long non-coding RNAs in the mouse cochlea.RNA biology · 2021Article
- A novel lincRNA identified in buffalo oocytes with protein binding characteristics could hold the key for oocyte competence.Molecular biology reports · 2021Article
- Epigenetic regulation of retinal development.Epigenetics & chromatin · 2021Review
- Dopamine 2 Receptor Signaling Controls the Daily Burst in Phagocytic Activity in the Mouse Retinal Pigment Epithelium.Investigative ophthalmology & visual science · 2020Article
- Sophisticated Gene Regulation for a Complex Physiological System: The Role of Non-coding RNAs in Photoreceptor Cells.Frontiers in cell and developmental biology · 2020Review
- Non-coding RNAs in retinal development and function.Human genetics · 2019Review
- Retinal Gene Distribution and Functionality Implicated in Inherited Retinal Degenerations Can Reveal Disease-Relevant Pathways for Pharmacologic Intervention.Pharmaceuticals (Basel, Switzerland) · 2019Article
- Genome-wide association analyses identify 139 loci associated with macular thickness in the UK Biobank cohort.Human molecular genetics · 2019Article
- Article
- A Combination of G Protein-Coupled Receptor Modulators Protects Photoreceptors from Degeneration.The Journal of pharmacology and experimental therapeutics · 2018Article
- Comparative genomic analyses highlight the contribution of pseudogenized protein-coding genes to human lincRNAs.BMC genomics · 2017Article
- LINC00461, a long non-coding RNA, is important for the proliferation and migration of glioma cells.Oncotarget · 2017Article
- Regulation of Noncoding Transcriptome in Developing Photoreceptors by Rod Differentiation Factor NRL.Investigative ophthalmology & visual science · 2017Article
- Genome-wide identification and expression profiling of long non-coding RNAs in auditory and vestibular systems.Scientific reports · 2017Article
- Precise long non-coding RNA modulation in visual maintenance and impairment.Journal of medical genetics · 2017Review
- arrEYE: a customized platform for high-resolution copy number analysis of coding and noncoding regions of known and candidate retinal dystrophy genes and retinal noncoding RNAs.Genetics in medicine : official journal of the American College of Medical Genetics · 2017Article
- Characterization of lincRNA expression in the human retinal pigment epithelium and differentiated induced pluripotent stem cells.PloS one · 2017Article
- Transcriptome analysis reveals rod/cone photoreceptor specific signatures across mammalian retinas.Human molecular genetics · 2016Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
The discovery that the mammalian transcriptome encodes thousands of long intergenic non-coding (linc) RNA transcripts, together with recent evidence that lincRNAs can regulate protein-coding genes, has added a new level of complexity to cellular transcriptional/translational regulation. Indeed several reports now link mutations in lincRNAs to heritable human disorders. Here, we identified a subset of lincRNAs in terminally differentiated adult human retinal neurons based on their sequence conservation across species. RNA sequencing of eye tissue from several mammalian species with varied rod/cone photoreceptor content identified 18 lincRNAs that were highly conserved across these species. Sixteen of the 18 were conserved in human retinal tissue with 14 of these also conserved in the macular region. A subset of lincRNAs exhibited restricted tissue expression profiles in mice, with preferential expression in the retina. Mouse models with different populations of retinal cells as well as in situ hybridization provided evidence that these lincRNAs localized to specific retinal compartments, most notably to the photoreceptor neuronal layer. Computational genomic loci and promoter region analyses provided a basis for regulated expression of these conserved lincRNAs in retinal post-mitotic neurons. This combined approach identified several lincRNAs that could be critical for retinal and visual maintenance in adults.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.