ArticleHuman molecular genetics2013
Genetic regulation of human adipose microRNA expression and its consequences for metabolic traits.
Article in Human molecular genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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Who cites it
53 citing papers in PubMed, 92 citations in OpenAlex.
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- The microRNA miR-30a blocks adipose tissue fibrosis accumulation in obesity.The Journal of clinical investigation · 2025Article
- Mapping the microRNA landscape in the older adult brain and its genetic contribution to neuropsychiatric conditions.Nature aging · 2025Article
- The Role of microRNA-22 in Metabolism.International journal of molecular sciences · 2025Review
- A comprehensive study of genetic regulation and disease associations of plasma circulatory microRNAs using population-level data.Genome biology · 2024Article
- Genetic regulation of microRNAs in the older adult brain and their contribution to neuropsychiatric conditions.bioRxiv : the preprint server for biology · 2024Article
- Myeloid-derived miR-6236 potentiates adipocyte insulin signaling and prevents hyperglycemia during obesity.Nature communications · 2024Article
- MicroRNA-22 Is a Key Regulator of Lipid and Metabolic Homeostasis.International journal of molecular sciences · 2023Article
- MicroRNA-eQTLs in the developing human neocortex link miR-4707-3p expression to brain size.eLife · 2023Article
- MicroRNA profiling of subcutaneous adipose tissue in periparturient dairy cows at high or moderate body condition.Scientific reports · 2022Article
- Genetic architecture of microRNA expression and its link to complex diseases in the Japanese population.Human molecular genetics · 2022Article
- A microRNA Cluster Controls Fat Cell Differentiation and Adipose Tissue Expansion By Regulating SNCG.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- Contributions of microRNAs to Peripheral Insulin Sensitivity.Endocrinology · 2022Review
- MitomiRs: their roles in mitochondria and importance in cancer cell metabolism.Radiology and oncology · 2021Review
- MicroRNA-204-5p reduction in rat hippocampus contributes to stress-induced pathology via targeting RGS12 signaling pathway.Journal of neuroinflammation · 2021Article
- Genetic regulation and heritability of miRNA and mRNA expression link to phosphorus utilization and gut microbiome.Open biology · 2021Article
- Urinary expression of long non-coding RNA TUG1 in non-diabetic patients with glomerulonephritides.Biomedical reports · 2021Article
- Oncogenic Landscape of Somatic Mutations Perturbing Pan-Cancer lncRNA-ceRNA Regulation.Frontiers in cell and developmental biology · 2021Article
- Article
- Identification of miRNA-eQTLs in maize mature leaf by GWAS.BMC genomics · 2020Article
Corrections and comments
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Authors and funding
13 authors at 3 institutions in 2 countries.
Funding
Abstract
The genetics of messenger RNA (mRNA) expression has been extensively studied in humans and other organisms, but little is known about genetic factors contributing to microRNA (miRNA) expression. We examined natural variation of miRNA expression in adipose tissue in a population of 200 men who have been carefully characterized for metabolic syndrome (MetSyn) phenotypes as part of the Metabolic Syndrome in Men (METSIM) study. We genotyped the subjects using high-density single-nucleotide polymorphism microarrays and quantified the mRNA abundance using genome-wide expression arrays and miRNA abundance using next-generation sequencing. We reliably quantified 356 miRNA species that were expressed in human adipose tissue, a limited number of which made up most of the expressed miRNAs. We mapped the miRNA abundance as an expression quantitative trait and determined cis regulation of expression for nine of the miRNAs and of the processing of one miRNA (miR-28). The degree of genetic variation of miRNA expression was substantially less than that of mRNAs. For the majority of the miRNAs, genetic regulation of expression was independent of the expression of mRNA from which the miRNA is transcribed. We also showed that for 108 miRNAs, mapped reads displayed widespread variation from the canonical sequence. We found a total of 24 miRNAs to be significantly associated with MetSyn traits. We suggest a regulatory role for miR-204-5p which was predicted to inhibit acetyl coenzyme A carboxylase β, a key fatty acid oxidation enzyme that has been shown to play a role in regulating body fat and insulin resistance in adipose tissue.
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Registered trials
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