Evidence map›Paper›PMID 23562538›Full record

ArticleVirology2013

Function and horizontal transfer of the small terminase subunit of the tailed bacteriophage Sf6 DNA packaging nanomotor.

Justin C Leavitt, Eddie B Gilcrease, Kassandra Wilson, Sherwood R Casjens

Abstract read
In one paragraph

Article in Virology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed.

  1. Article
  2. Article
  3. The TolC and Lipopolysaccharide-SpecificPHAGE (New Rochelle, N.Y.) · 2024
    Article
  4. Article
  5. Article
  6. Article
  7. Hybrid Vigor: Importance of Hybrid λ Phages in Early Insights in Molecular Biology.Microbiology and molecular biology reviews : MMBR · 2022
    Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Ecology, Structure, and Evolution ofAnnual review of virology · 2020
    Review
  15. Article
  16. Article
  17. DNA Packaging and Genomics of theJournal of virology · 2019
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Justin C LeavittBiology Department, University of Utah, Salt Lake City, UT 84112, USA.
Eddie B Gilcrease
Kassandra Wilson
Sherwood R Casjens

Funding

DNA packaging and delivery by dsDNA virusesR01AI074825 · NIAID · UNIVERSITY OF UTAH · PI CASJENS, SHERWOOD R. · 2008 to 2012
$1.8M
NIAID NIH HHS R01 AI074825NIAID NIH HHS R01AI074825
6 · The paper itself

Abstract

Bacteriophage Sf6 DNA packaging series initiate at many locations across a 2kbp region. Our in vivo studies show that Sf6 small terminase subunit (TerS) protein recognizes a specific packaging (pac) site near the center of this region, that this site lies within the portion of the Sf6 gene that encodes the DNA-binding domain of TerS protein, that this domain of the TerS protein is responsible for the imprecision in Sf6 packaging initiation, and that the DNA-binding domain of TerS must be covalently attached to the domain that interacts with the rest of the packaging motor. The TerS DNA-binding domain is self-contained in that it apparently does not interact closely with the rest of the motor and it binds to a recognition site that lies within the DNA that encodes the domain. This arrangement has allowed the horizontal exchange of terS genes among phages to be very successful.

Indexed as

DNA PackagingAmino Acid SequenceBacteriophagesDNA-Binding ProteinsDNA, ViralEndodeoxyribonucleasesModels, MolecularMolecular Sequence DataPhylogenyProtein SubunitsSequence Homology, Amino AcidViral ProteinsDNA-Binding ProteinsDNA, ViralEndodeoxyribonucleasesProtein SubunitsterminaseViral Proteins

Identifiers

PMID23562538
PMCPMC3643300

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.