ReviewCurrent opinion in neurobiology2013
A sleep state during C. elegans development.
Review in Current opinion in neurobiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- A circadian clock gene homolog regulates developmental timing and male mating circuitry iniScience · 2026Article
- Roles of Cyclic Nucleotide Phosphodiesterases in Signal Transduction Pathways in the NematodeCells · 2025Review
- Structural neuroplasticity after sleep loss modifies behavior and requires neurexin and neuroligin.iScience · 2024Article
- Parp1 promotes sleep, which enhances DNA repair in neurons.Molecular cell · 2021Article
- Article
- Melatonin promotes sleep by activating the BK channel inProceedings of the National Academy of Sciences of the United States of America · 2020Article
- Stress and timing associated withHeliyon · 2020Article
- RPamide neuropeptides NLP-22 and NLP-2 act through GnRH-like receptors to promote sleep and wakefulness in C. elegans.Scientific reports · 2020Article
- Automated detection and manipulation of sleep in C. elegans reveals depolarization of a sleep-active neuron during mechanical stimulation-induced sleep deprivation.Scientific reports · 2018Article
- Alzheimer's Disease and Sleep-Wake Disturbances: Amyloid, Astrocytes, and Animal Models.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Review
- The Sleep in Caenorhabditis elegans: What We Know Until Now.Molecular neurobiology · 2018Review
- Article
- Review
- A Conserved GEF for Rho-Family GTPases Acts in an EGF Signaling Pathway to Promote Sleep-like Quiescence in Caenorhabditis elegans.Genetics · 2016Article
- Deriving Shape-Based Features for C. elegans Locomotion Using Dimensionality Reduction Methods.Frontiers in behavioral neuroscience · 2016Article
- Distinct Mechanisms Underlie Quiescence during Two Caenorhabditis elegans Sleep-Like States.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Homeostasis in C. elegans sleep is characterized by two behaviorally and genetically distinct mechanisms.eLife · 2014Article
- VAV-1 acts in a single interneuron to inhibit motor circuit activity in Caenorhabditis elegans.Nature communications · 2014Article
- Article
- Unraveling the complexities of circadian and sleep interactions with memory formation through invertebrate research.Frontiers in systems neuroscience · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Caenorhabditis elegans is the simplest animal shown to sleep. It sleeps during lethargus, a larval transition stage. Behavior during lethargus has the sleep properties of a specific quiescent posture and elevated arousal threshold that are reversible to strong stimulation and of increased sleep drive following sleep deprivation. Genetic similarities between sleep regulation during C. elegans lethargus and sleep regulation in other animals point to a sleep state that was an evolutionarily ancestor to sleep both in C. elegans and other animals. Recent publications have shed light on key questions in sleep biology: First, How is sleep regulated? Second, How is sensory information gated during sleep? Third, How is sleep homeostasis mediated? Fourth, What is the core function of sleep?
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.