Evidence map›Paper›PMID 23562364›Full record

Trial reportJournal of clinical densitometry : the official journal of the International Society for Clinical Densitometry

Vertebral fracture assessment in adolescents and young women with anorexia nervosa: a case series.

Amy D Divasta, Henry A Feldman, Catherine M Gordon

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00310791 (Effects of Adrenal and Gonadal Hormone Replacement in Young Women With Anorexia Nervosa), which is not on this map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
5.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00310791 phase2 / phase3completednot on this map

Effects of Adrenal and Gonadal Hormone Replacement in Young Women With Anorexia Nervosa

TypeinterventionalSponsorBoston Children's HospitalRan2004 to 2010Enrolled80ConditionsAnorexia NervosaArmsHormone replacement therapy (estrogen/progestin), Placebo (Sugar Pill), Dehydroepiandrosterone (DHEA)
3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 25 citations in OpenAlex.

  1. Effects of teriparatide on hip structure and bone microarchitecture in women with anorexia nervosa: a placebo-controlled randomized trial.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026
    Trial
  2. Trial
  3. Bone densitometry findings and prevalence of osteoporosis at initial scanning in girls with anorexia nervosa.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026
    Article
  4. Bone marrow adipose tissue is associated with fracture history in anorexia nervosa.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2022
    Article
  5. Review
  6. Review
  7. Article
  8. Assessment of Sex Differences in Fracture Risk Among Patients With Anorexia Nervosa: A Population-Based Cohort Study Using The Health Improvement Network.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2017
    Article
  9. Review
  10. The management of osteoporosis in children.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2016
    Review
  11. Skeletal complications of eating disorders.Metabolism: clinical and experimental · 2015
    Review
  12. Anorexia nervosa and bone.The Journal of endocrinology · 2014
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Amy D DivastaDivision of Adolescent Medicine, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA; Division of Gynecology, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA. Electronic address: amy.divasta@childrens.harvard.edu.
Henry A FeldmanClinical Research Program and Division of Endocrinology, Boston Children's Hospital, Boston, MA, USA.
Catherine M GordonDivision of Adolescent Medicine, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA; Division of Adolescent Medicine, Hasbro Children's Hospital and Brown University, Providence, RI, USA; Division of Endocrinology, Hasbro Children's Hospital and Brown University, Providence, RI, USA.
Boston Children's Hospital · USBrown University · US

Funding

Effects of Adrenal and Gonadal HR in Young Women with ANR01HD043869 · NICHD · CHILDREN'S HOSPITAL BOSTON · PI GORDON, CATHERINE M. · 2004 to 2010
$1.7M
Effect of Adrenal and Gonadal Hormones on Bone Marrow and Appendicular BMDR01AR060829 · NIAMS · RHODE ISLAND HOSPITAL · PI GORDON, CATHERINE M. · 2011 to 2015
$1.4M
Biomechanical Stimulation & Skeletal Health in Adolescents with Anorexia NervosaK23HD060066 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI DIVASTA, AMY D · 2009 to 2013
$656k
NIAMS NIH HHS R01 AR060829NICHD NIH HHS K23 HD060066NICHD NIH HHS R01 HD043869
6 · The paper itself

Abstract

Rates of vertebral fracture (VF) in young women with anorexia nervosa (AN) are not well understood. We sought to determine the rates of asymptomatic VF in patients suffering from AN, hypothesizing that VF rates would be higher in subjects with low bone mineral density (BMD) Z-scores. We recruited young women with AN (n = 80) for participation in a longitudinal trial. Dual-energy X-ray absorptiometry images of the lateral thoracic and lumbar spines were obtained for VF assessment at 0, 6, 12, and 18 mo. Thirteen subjects (16%) had a low spinal BMD at baseline (BMD Z-score ≤-2 standard deviation). Using the Genant semiquantitative technique, 2 of 80 subjects at baseline (2.5%) had evidence of a single Genant grade 1 deformity. One subject had a Genant grade 2 deformity. Over the 18-mo trial, 10 incident VFs occurred in 9 subjects (12.5%). Using quantitative techniques, only 2 subjects had a more than 15% loss in vertebral height. Neither anthropometric data nor markers of disease severity were associated with fracture. In conclusion, ill young women with AN were at low risk for asymptomatic VF in our cohort. VFs were not predicted by duration of illness, severity of malnutrition, or traditional measures of areal BMD at the lumbar spine.

Indexed as

Absorptiometry, PhotonAdjuvants, ImmunologicAdolescentAdultAge FactorsAnorexia NervosaBone DensityCohort StudiesDehydroepiandrosteroneFemaleHormone Replacement TherapyHumansIncidenceLumbar VertebraeRisk FactorsSpinal FracturesAdjuvants, ImmunologicDehydroepiandrosteroneAdolescentsanorexia nervosavertebral fracturevertebral fracture assessment

Identifiers

PMID23562364
PMCPMC3743948
OpenAlexW2011992674

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.