ArticleCell reports2013
Definition of RNA polymerase II CoTC terminator elements in the human genome.
Article in Cell reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 31 citations in OpenAlex.
- Fateful Decisions of Where to Cut the Line: Pathology Associated with Aberrant 3' End Processing and Transcription Termination.Journal of molecular biology · 2025Review
- CRIMP: a CRISPR/Cas9 insertional mutagenesis protocol and toolkit.Nature communications · 2024Article
- Post-transcriptional polyadenylation site cleavage maintains 3'-end processing upon DNA damage.The EMBO journal · 2023Article
- Structural basis for RNA surveillance by the human nuclear exosome targeting (NEXT) complex.Cell · 2022Article
- Article
- mRNA Editing, Processing and Quality Control inGenetics · 2020Review
- Metabolic and Redox Signaling of the Nucleoredoxin-Like-1 Gene for the Treatment of Genetic Retinal Diseases.International journal of molecular sciences · 2020Review
- Dismissal of RNA Polymerase II Underlies a Large Ligand-Induced Enhancer Decommissioning Program.Molecular cell · 2018Article
- Article
- Transcriptional termination in mammals: Stopping the RNA polymerase II juggernaut.Science (New York, N.Y.) · 2016Review
- Mammalian NET-seq analysis defines nascent RNA profiles and associated RNA processing genome-wide.Nature protocols · 2016Article
- Article
- Effects of Transcription Elongation Rate and Xrn2 Exonuclease Activity on RNA Polymerase II Termination Suggest Widespread Kinetic Competition.Molecular cell · 2015Article
- Article
- Transcription termination and the control of the transcriptome: why, where and how to stop.Nature reviews. Molecular cell biology · 2015Review
- BRCA1 recruitment to transcriptional pause sites is required for R-loop-driven DNA damage repair.Molecular cell · 2015Article
- Fail-safe transcription termination: Because one is never enough.RNA biology · 2015Review
- Article
- Terminate and make a loop: regulation of transcriptional directionality.Trends in biochemical sciences · 2014Review
- Coupling mRNA processing with transcription in time and space.Nature reviews. Genetics · 2014Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Mammalian RNA polymerase II (Pol II) transcription termination is an essential step in protein-coding gene expression that is mediated by pre-mRNA processing activities and DNA-encoded terminator elements. Although much is known about the role of pre-mRNA processing in termination, our understanding of the characteristics and generality of terminator elements is limited. Whereas promoter databases list up to 40,000 known and potential Pol II promoter sequences, fewer than ten Pol II terminator sequences have been described. Using our knowledge of the human β-globin terminator mechanism, we have developed a selection strategy for mapping mammalian Pol II terminator elements. We report the identification of 78 cotranscriptional cleavage (CoTC)-type terminator elements at endogenous gene loci. The results of this analysis pave the way for the full understanding of Pol II termination pathways and their roles in gene expression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.