ArticleJournal of the American Association for Laboratory Animal Science : JAALAS2013
Repeated administration of tribromoethanol in C57BL/6NHsd mice.
Article in Journal of the American Association for Laboratory Animal Science : JAALAS, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 16 citations in OpenAlex.
- Revisiting MAC as a static measure of anaesthesia: evidence for dynamic responses under isoflurane in male mice.British journal of anaesthesia · 2026Article
- IRF1 regulates apoptosis and osteogenic differentiation of bone marrow mesenchymal stem cells and ameliorates osteoporosis by activating the PI3K/AKT signaling pathway.Journal of advanced research · 2026Article
- NeuroD1-based in situ neural regeneration for the treatment of radiation-induced brain injury.Neural regeneration research · 2026Article
- Repurposing metformin for treating osteoarthritis via leveraging Nrf2 signaling.Scientific reports · 2026Article
- Ulk1-dependent alternative mitophagy plays a protective role during pressure overload in the heart.Cardiovascular research · 2022Article
- Mouse Anesthesia: The Art and Science.ILAR journal · 2021Review
- Effects of Oxygen Supplementation on Injectable and Inhalant Anesthesia in C57BL/6 Mice.Journal of the American Association for Laboratory Animal Science : JAALAS · 2021Article
- Effect of Stereotaxic Surgery of the Third Ventricle on Growth Performance in Neonatal Chicks.The journal of poultry science · 2020Article
- The effect of avertin anesthesia and a mixture of three types of anesthetic agents on food intakeand body weight in high fat-induced obese maleand female mice.Experimental animals · 2019Article
- Alfaxalone-Xylazine Anesthesia in Laboratory Mice (Journal of the American Association for Laboratory Animal Science : JAALAS · 2019Article
- Comparison of the anesthetic effects of 2,2,2-tribromoethanol on ICR mice derived from three different sources.Laboratory animal research · 2018Article
- Effect of Radiation on Sucrose Detection Thresholds of Mice.Chemical senses · 2017Article
- Refinements for embryo implantation surgery in the mouse: comparison of injectable and inhalant anesthesias - tribromoethanol, ketamine and isoflurane - on pregnancy and pup survival.Laboratory animals · 2016Article
- Intraperitoneal Continuous-Rate Infusion for the Maintenance of Anesthesia in Laboratory Mice (Mus musculus).Journal of the American Association for Laboratory Animal Science : JAALAS · 2016Article
- Comparison of Heart Rate and Blood Pressure with Toe Pinch and Bispectral Index for Monitoring the Depth of Anesthesia in Piglets.Journal of the American Association for Laboratory Animal Science : JAALAS · 2015Article
- Best anesthetics for assessing left ventricular systolic function by echocardiography in mice.American journal of physiology. Heart and circulatory physiology · 2015Article
- Dose regimens, variability, and complications associated with using repeat-bolus dosing to extend a surgical plane of anesthesia in laboratory mice.Journal of the American Association for Laboratory Animal Science : JAALAS · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We evaluated the effect of repeated intraperitoneal administration of tribromoethanol on various parameters in C57BL/6NHsd mice. Mice (n = 68) were randomly assigned to 1 of 7 groups to receive tribromoethanol (500 mg/kg IP) on day 0 or days 0 and 8; vehicle (tert-amyl alcohol in sterile water) only on day 0 or days 0 and 8; sterile water injection on day 0 or days 0 and 8; or no treatment. A single dose of tribromoethanol failed to produce loss of pedal reflex and had no effect on median food and water consumption but altered median body weight on days 1 through 4 when compared with that in mice that received vehicle only or no treatment. Median body weight did not differ between mice that received a single dose of tribromoethanol and those that received an injection of water. Among mice given 2 doses of tribromoethanol, induction time, anesthetic duration, and recovery time varied widely. Repeated administration of tribromoethanol had no effect on median food and water consumption or body weight compared with those in controls. Median liver weight was significantly greater in mice that received 2 doses compared with a single dose of tribromoethanol. Median liver weight did not differ between untreated mice and those that received tribromoethanol. No significant organ or tissue pathology was observed in any study animal. Although tribromoethanol did not produce morbidity, mortality, or pathologic changes in treated animals, we urge caution in use of tribromoethanol in C57BL/6NHsd mice due to its variable anesthetic effectiveness.
Indexed as
Identifiers
23562101PMC3624786W1534603744What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.