ArticleJournal of the American Association for Laboratory Animal Science : JAALAS2013
Unsterilized feed as the apparent cause of a mouse parvovirus outbreak.
Article in Journal of the American Association for Laboratory Animal Science : JAALAS, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed.
- Evaluation of sterility testing procedures for laboratory animal rodent diets.Veterinary and animal science · 2026Article
- Effects of supplementary protein source, autoclaving diets, and gender on biochemical blood parameters, oxidative stress markers, and caecal fermentation in rats.BMC veterinary research · 2026Article
- Guidance on Establishing Health Monitoring Panels for Laboratory Mice to Reflect Contemporary Pathogen Prevalence.Journal of the American Association for Laboratory Animal Science : JAALAS · 2025Review
- Corneal Changes and Strategies to Improve Survival of Hypomorphic Collagen VII-Deficient Mice for the Study of Ocular Dystrophic Epidermolysis Bullosa.Comparative medicine · 2022Article
- Assessing Elimination of Mouse Kidney Parvovirus from Cages by Mechanical Washing.Journal of the American Association for Laboratory Animal Science : JAALAS · 2022Article
- The Influence of Feed and Drinking Water on Terrestrial Animal Research and Study Replicability.ILAR journal · 2020Article
- Compressed Paper as an Alternative to Corn Cob Bedding in Mouse (Journal of the American Association for Laboratory Animal Science : JAALAS · 2020Article
- Adverse Effects of Autoclaved Diets on the Progression of Chronic Kidney Disease and Chronic Kidney Disease-Mineral Bone Disorder in Rats.American journal of nephrology · 2020Article
- Effects of Pelleting, Irradiation, and Autoclaving of Rodent Feed on MPV and MNV Infectivity.Journal of the American Association for Laboratory Animal Science : JAALAS · 2019Article
- Immune Relevant and Immune Deficient Mice: Options and Opportunities in Translational Research.ILAR journal · 2018Review
- Contaminated Shipping Materials Identified as the Source of Rotaviral Infection of Exported Mice.Journal of the American Association for Laboratory Animal Science : JAALAS · 2018Article
- Results of Survey Regarding Prevalence of Adventitial Infections in Mice and Rats at Biomedical Research Facilities.Journal of the American Association for Laboratory Animal Science : JAALAS · 2017Article
- Effect of Cage-Wash Temperature on the Removal of Infectious Agents from Caging and the Detection of Infectious Agents on the Filters of Animal Bedding-Disposal Cabinets by PCR Analysis.Journal of the American Association for Laboratory Animal Science : JAALAS · 2015Article
- Transmission of mouse parvovirus by fomites.Journal of the American Association for Laboratory Animal Science : JAALAS · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In early 2009, we experienced a widespread outbreak of mouse parvoviruses 1 and 2 (MPV) at our institution, which encompasses approximately 50,000 cages located in 7 campus vivaria. MPV had not been detected for several years; however, during a single 4-mo sentinel-testing rotation comprising all racks at the institution, 72 of 927 rack sentinels tested serologically positive for MPV1, MPV2, or both. PCR of fecal samples from several index cases confirmed MPV. Each sentinel-positive rack contained between 0 and 10 infected colony cages. Positive racks appeared to be randomly distributed, although several small facilities escaped infection. We investigated how this infection may have entered the facilities, in which mice were maintained in barrier caging with sterilized feed, bedding, and equipment, and procedures were in place to prevent incoming infection and cross-contamination. The only widespread change that occurred during the 3 mo preceding the first positive test was that every cage had been treated for 12 wk with an unsterilized fenbendazole-medicated diet. At the completion of fenbendazole treatment, sterilized feed was reinstituted. Evidence of MPV infection was eliminated within 7 mo via an intensive test-and-remove policy in combination with movement controls, and we have had no further positive tests in the 3.5 y since the outbreak. Although the possibility remains that MPV infection resulted from fomites or undetected infections in incoming mice, the timing and extent of this outbreak together with the complete absence of new cases after sterilized feed was reinstituted strongly implicate unsterilized feed as the source of this MPV outbreak.
Indexed as
Identifiers
23562038PMC3548206What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.