ReviewComparative medicine2012
Transgenic rabbit models for studying human cardiovascular diseases.
Review in Comparative medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 32 citations in OpenAlex.
- Transgenesis in Drug Discovery: Enhancing Target Identification and Validation.Molecular biotechnology · 2026Review
- From Bench to Bedside: Translational Approaches to Cardiotoxicity in Breast Cancer, Lung Cancer, and Lymphoma Therapies.Cancers · 2025Review
- Integrating Computational and Biological Hemodynamic Approaches to Improve Modeling of Atherosclerotic Arteries.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Review
- Development of a novel castration-resistant orthotopic prostate cancer model in New Zealand White rabbit.The Prostate · 2022Article
- Preclinical models of radiation-induced cardiac toxicity: Potential mechanisms and biomarkers.Frontiers in oncology · 2022Review
- Genetically Modified Rabbits for Cardiovascular Research.Frontiers in genetics · 2021Review
- Genome engineering technologies in rabbits.Journal of biomedical research · 2020Article
- Rabbit induced pluripotent stem cells retain capability of in vitro cardiac differentiation.Experimental animals · 2019Article
- Significant role and mechanism of microRNA-143-3p/KLLN axis in the development of coronary heart disease.American journal of translational research · 2019Article
- Improving Surgical Methods for Studying Vascular Grafts in Animal Models.Tissue engineering. Part C, Methods · 2018Article
- Rapid detection of three rabbit pathogens by use of the Luminex x-TAG assay.BMC veterinary research · 2018Article
- Principles and Applications of Rabbit Models for Atherosclerosis Research.Journal of atherosclerosis and thrombosis · 2018Review
- Comparative studies of three cholesteryl ester transfer proteins and their interactions with known inhibitors.PloS one · 2017Article
- Rabbit models of cardiac mechano-electric and mechano-mechanical coupling.Progress in biophysics and molecular biology · 2016Review
- Rabbit Models for Studying Human Infectious Diseases.Comparative medicine · 2015Review
- Animal models of coronary heart disease.Journal of biomedical research · 2015Article
- Rabbit models for the study of human atherosclerosis: from pathophysiological mechanisms to translational medicine.Pharmacology & therapeutics · 2015Review
- Development of Antiatherosclerotic Drugs on the basis of Natural Products Using Cell Model Approach.Oxidative medicine and cellular longevity · 2015Review
- Staphylococcal toxic shock syndrome: superantigen-mediated enhancement of endotoxin shock and adaptive immune suppression.Immunologic research · 2014Review
- Models matter: the search for an effective Staphylococcus aureus vaccine.Nature reviews. Microbiology · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cardiovascular diseases involve the heart or blood vessels and remain a leading cause of morbidity and mortality in developed countries. A variety of animal models have been used to study cardiovascular diseases and have contributed to our understanding of their pathophysiology and treatment. However, mutations or abnormal expression of specific genes play important roles in the pathophysiology of some heart diseases, for which a closely similar animal model often is not naturally available. With the advent of techniques for specific genomic modification, several transgenic and knockout mouse models have been developed for cardiovascular conditions that result from spontaneous mutations. However, mouse and human heart show marked electrophysiologic differences. In addition, cardiac studies in mouse models are extremely difficult because of their small heart size and fast heart rate. Therefore, larger genetically engineered animal models are needed to overcome the limitations of the mouse models. This review summarizes the transgenic rabbit models that have been developed to study cardiovascular diseases.
Indexed as
Identifiers
23561880PMC3527751W276105048What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.