Evidence map›Paper›PMID 23561439›Full record

ArticleCell stem cell2013

If a stem cell dies in the crypt, and no one is around to see it….

Ysbrand M Nusse, Ophir D Klein

Abstract readComment
PubMed Publisher
In one paragraph

Article in Cell stem cell, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Transit Amplifying Cells (TACs): a still not fully understood cell population.Frontiers in bioengineering and biotechnology · 2023
    Review
  2. The mammary cellular hierarchy and breast cancer.Cellular and molecular life sciences : CMLS · 2014
    Review
  3. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Ysbrand M NusseBiomedical Sciences Graduate Program, Program in Craniofacial and Mesenchymal Biology, University of California, San Francisco, San Francisco, CA 94143, USA.
Ophir D Klein

Funding

PREDOCTORAL TRAINING IN DEVELOPMENTAL BIOLOGYT32HD007470 · NICHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Todd Nystul · 1994 to 2026
$7.7M
NICHD NIH HHS T32 HD007470
6 · The paper itself

Abstract

Two recent studies continue the debate regarding lineage and hierarchy in the intestinal epithelium. One reports that quiescent crypt cells are Paneth cell precursors (Buczacki et al., 2013). The second shows that tamoxifen induces apoptosis in crypt cells and that suppressing apoptosis alters lineage tracing patterns (Zhu et al., 2013).

Identifiers

PMID23561439

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.