ArticleNucleic acids research1990
Two separable promoters control different aspects of expression of a Dictyostelium gene.
Article in Nucleic acids research, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Preferential deadenylation of Hsp70 mRNA plays a key role in regulating Hsp70 expression in Drosophila melanogaster.Molecular and cellular biology · 1994Article
- Two transmembrane signaling mechanisms control expression of the cAMP receptor gene CAR1 during Dictyostelium development.Proceedings of the National Academy of Sciences of the United States of America · 1993Article
- Evidence for a feedback regulated back-up promoter which controls permanent expression of a Dictyostelium gene.Nucleic acids research · 1990Article
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Authors and funding
2 authors.
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Abstract
A single copy Dictyostelium gene was dissected and elements responsible for its complex pattern of regulation were defined by transcript analysis of gene fusions. Two overlapping promoters responsible for the transcription of an 'L' and an 'S' mRNA could be defined. Further dissection of the P8A7 L promoter resulted in the identification of a sequence necessary for stress induction and an element required for vegetative expression. The P8A7 S promoter could be reduced to 449 bp which were sufficient for expression in developing cells. The sequence element required for this transcriptional activity was shown to reside in a 51 bp fragment. Our results show that differential expression of the P8A7 gene is mediated by two independently functioning promoters which, however, share some regulatory elements. A third nuclear RNA species 'P' was due to the stress-sensitivity of the 3' processing signal.
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