ArticleTwin research and human genetics : the official journal of the International Society for Twin Studies2013
How phenotype and developmental stage affect the genes we find: GABRA2 and impulsivity.
Article in Twin research and human genetics : the official journal of the International Society for Twin Studies, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 50 citations in OpenAlex.
- Genes associated with alcohol outcomes show enrichment of effects with broad externalizing and impulsivity phenotypes in an independent sample.Journal of studies on alcohol and drugs · 2015Trial
- The collaborative study on the genetics of alcoholism: Sample and clinical data.Genes, brain, and behavior · 2023Review
- Genetic Risk, Neighborhood Characteristics, and Behavioral Difficulties Among African American Adolescents Living in Very Low-Income Neighborhoods.Research on child and adolescent psychopathology · 2023Article
- Predictors of Increases in Alcohol Problems and Alcohol Use Disorders in Offspring in the San Diego Prospective Study.Alcoholism, clinical and experimental research · 2019Article
- Genetic influences on conduct disorder.Neuroscience and biobehavioral reviews · 2018Review
- Innately activated TLR4 signal in the nucleus accumbens is sustained by CRF amplification loop and regulates impulsivity.Brain, behavior, and immunity · 2018Article
- CYP2A6 metabolism in the development of smoking behaviors in young adults.Addiction biology · 2018Article
- Genetic analysis of impulsive personality traits: Examination of a priori candidates and genome-wide variation.Psychiatry research · 2018Article
- PROSPER Intervention Effects on Adolescents' Alcohol Misuse Vary by GABRA2 Genotype and Age.Prevention science : the official journal of the Society for Prevention Research · 2018Article
- Variation in SWI/SNF Chromatin Remodeling Complex Proteins is Associated with Alcohol Dependence and Antisocial Behavior in Human Populations.Alcoholism, clinical and experimental research · 2017Article
- An endophenotype approach to the genetics of alcohol dependence: a genome wide association study of fast beta EEG in families of African ancestry.Molecular psychiatry · 2017Article
- A GABRA2 polymorphism improves a model for prediction of drinking initiation.Alcohol (Fayetteville, N.Y.) · 2017Article
- A Prospective Comparison of How the Level of Response to Alcohol and Impulsivity Relate to Future DSM-IV Alcohol Problems in the COGA Youth Panel.Alcoholism, clinical and experimental research · 2017Article
- Roles of Response Inhibition and Gene-Environment Interplay in Pathways to Adolescents' Externalizing Problems.Journal of research on adolescence : the official journal of the Society for Research on Adolescence · 2017Article
- A KCNJ6 gene polymorphism modulates theta oscillations during reward processing.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2017Article
- A genome wide association study of fast beta EEG in families of European ancestry.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2017Article
- Oppositional defiant disorder: current insight.Psychology research and behavior management · 2017Review
- Article
- Genetic influences on adolescent behavior.Neuroscience and biobehavioral reviews · 2016Review
- TLR4 signaling in VTA dopaminergic neurons regulates impulsivity through tyrosine hydroxylase modulation.Translational psychiatry · 2016Article
Corrections and comments
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Authors and funding
15 authors at 8 institutions in 1 country.
Funding
Abstract
contextThe detection and replication of genes involved in psychiatric outcome has been notoriously difficult. Phenotypic measurement has been offered as one explanation, although most of this discussion has focused on problems with binary diagnoses.
objectiveThis article focuses on two additional components of phenotypic measurement that deserve further consideration in evaluating genetic associations: (1) the measure used to reflect the outcome of interest, and (2) the developmental stage of the study population. We focus our discussion of these issues around the construct of impulsivity and externalizing disorders, and the association of these measures with a specific gene, GABRA2. DESIGN, SETTING, AND
participantsData were analyzed from the Collaborative Study on the Genetics of Alcoholism Phase IV assessment of adolescents and young adults (ages 12-26; N = 2,128).
main outcome measuresAlcohol dependence, illicit drug dependence, childhood conduct disorder, and adult antisocial personality disorder symptoms were measured by psychiatric interview; Achenbach youth/adult self-report externalizing scale; Zuckerman Sensation-Seeking scale; Barratt Impulsivity scale; NEO extraversion and consciousness.
resultsGABRA2 was associated with subclinical levels of externalizing behavior as measured by the Achenbach in both the adolescent and young adult samples. Contrary to previous associations in adult samples, it was not associated with clinical-level DSM symptom counts of any externalizing disorders in these younger samples. There was also association with sensation-seeking and extraversion, but only in the adolescent sample. There was no association with the Barratt impulsivity scale or conscientiousness.
conclusionsOur results suggest that the pathway by which GABRA2 initially confers risk for eventual alcohol problems begins with a predisposition to sensation-seeking early in adolescence. The findings support the heterogeneous nature of impulsivity and demonstrate that both the measure used to assess a construct of interest and the age of the participants can have profound implications for the detection of genetic associations.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.