ArticleBMC complementary and alternative medicine2013
Regulation of podocalyxin expression in the kidney of streptozotocin-induced diabetic rats with Chinese herbs (Yishen capsule).
Article in BMC complementary and alternative medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Chinese herbal medicine and its active compounds in attenuating renal injuryFrontiers in endocrinology · 2023Pooled it
- Long-term clinical effect of Tangyiping Granules () on patients with impaired glucose tolerance.Chinese journal of integrative medicine · 2016Trial
- Cepharanthine improves blood glucose levels and mitigates renal injury in streptozotocin-induced diabetic rats via restoring pancreatic β-cell integrity and reducing inflammation.Frontiers in pharmacology · 2026Article
- Yishen Capsule Alleviated Symptoms of Diabetic Nephropathy via NOD-like Receptor Signaling Pathway.Diabetes, metabolic syndrome and obesity : targets and therapy · 2022Article
- Network pharmacology study of Yishen capsules in the treatment of diabetic nephropathy.PloS one · 2022Article
- Yishen capsule promotes podocyte autophagy through regulating SIRT1/NF-κB signaling pathway to improve diabetic nephropathy.Renal failure · 2021Article
- Integrated Metabolomics and Network Pharmacology to Establish the Action Mechanism of Qingrekasen Granule for Treating Nephrotic Syndrome.Frontiers in pharmacology · 2021Article
- Potential application of nanoemulsified garlic oil blend in mitigating the progression of type 2 diabetes-mediated nephropathy in Wistar rats.3 Biotech · 2020Article
- Amelioration of experimentally induced diabetic nephropathy and renal damage by nilotinib.Journal of physiology and biochemistry · 2015Article
- Qiwei granules alleviates podocyte lesion in kidney of diabetic KK-Ay mice.BMC complementary and alternative medicine · 2015Article
- Chinese medicine Jinlida (JLD) ameliorates high-fat-diet induced insulin resistance in rats by reducing lipid accumulation in skeletal muscle.International journal of clinical and experimental medicine · 2015Article
- Metformin Ameliorates Podocyte Damage by Restoring Renal Tissue Podocalyxin Expression in Type 2 Diabetic Rats.Journal of diabetes research · 2015Article
- Inhibition of adriamycin-induced nephropathy in rats by herbs based kangshenoral solution.International journal of clinical and experimental medicine · 2015Article
- Effect of bilirubin on triglyceride synthesis in streptozotocin-induced diabetic nephropathy.Journal of Korean medical science · 2014Article
- Hypoglycemic effect of polysaccharides with different molecular weight of Pseudostellaria heterophylla.BMC complementary and alternative medicine · 2013Article
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDiabetic nephropathy is an emergent issue in China with increase in patients with type II diabetes. There are several successful Chinese herbal products for the treatment of patients with diabetic nephropathy in China. However, the mechanisms mediating the biological activity of these products are still unclear. Podocalyxin is a sialoprotein critical to maintaining integrity of filtration function of glomerulus.
methodsBy employing streptozotocin-induced diabetic rats and a Chinese herb formulation (Yishen capsule), we examined the regulation of podocalyxin expression in the kidney by Yishen capsule through immunofluorescent staining and reverse transcriptase polymerase chain reaction.
resultsAfter injection of STZ, there were significant increase in both blood glucose and urinary protein. Serum creatinine and BUN were also increased in rats with injection of STZ. Moreover, expression of podocalyxin in the glomerulus was gradually reduced after injection of STZ. There was also a loss of podocyte foot processes in the glomerular basement membrane. However, Yishen capsule or benazepril was able to restore the expression of podocalyxin and podocyte foot processes in the kidney. Although Yishen capsule could reduce urinary protein level, it has little effect on blood glucose level in the rats injected with STZ.
conclusionsYishen capsule could attenuate the loss of podocalyxin in the glomerulus of rats injected with STZ.
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