ArticleAnalytical chemistry2013
A localized surface plasmon resonance imaging instrument for multiplexed biosensing.
Article in Analytical chemistry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Strategies for Multiplexing Plasmonic Biosensing.Sensors (Basel, Switzerland) · 2026Review
- Direct Detection ofSensors (Basel, Switzerland) · 2025Article
- Plasmonic Nanopillars-A Brief Investigation of Fabrication Techniques and Biological Applications.Biosensors · 2023Review
- Article
- Growth of Highly-Ordered Metal Nanoparticle Arrays in the Dimpled Pores of an Anodic Aluminum Oxide Template.Nanomaterials (Basel, Switzerland) · 2022Article
- Maximizing the Surface Sensitivity of LSPR Biosensors through Plasmon Coupling-Interparticle Gap Optimization for Dimers Using Computational Simulations.Biosensors · 2021Article
- Dip-Pen Nanolithography(DPN): from Micro/Nano-patterns to Biosensing.Chemical research in Chinese universities · 2021Review
- Opportunities and Challenges for Biosensors and Nanoscale Analytical Tools for Pandemics: COVID-19.ACS nano · 2020Review
- Large Scale Fabrication of Ordered Gold Nanoparticle-Epoxy Surface Nanocomposites and Their Application as Label-Free Plasmonic DNA Biosensors.ACS applied materials & interfaces · 2020Article
- Optical Interrogation Techniques for Nanophotonic Biochemical Sensors.Sensors (Basel, Switzerland) · 2019Review
- Quantitative Comparison of Protein Adsorption and Conformational Changes on Dielectric-Coated Nanoplasmonic Sensing Arrays.Sensors (Basel, Switzerland) · 2018Article
- Highly Sensitive Plasmonic Detection of the Pancreatic Cancer Biomarker CA 19-9.Scientific reports · 2017Article
- Flexible and Tunable 3D Gold Nanocups Platform as Plasmonic Biosensor for Specific Dual LSPR-SERS Immuno-Detection.Scientific reports · 2017Article
- Superior LSPR substrates based on electromagnetic decoupling for on-a-chip high-throughput label-free biosensing.Light, science & applications · 2017Article
- Wavelength-Scanning SPR Imaging Sensors Based on an Acousto-Optic Tunable Filter and a White Light Laser.Sensors (Basel, Switzerland) · 2017Article
- Plasmonic nanodisc arrays on calcinated titania for multimodal analysis of phosphorylated peptides.RSC advances · 2017Article
- Peptide Functionalized Nanoplasmonic Sensor for Explosive Detection.Nano-micro letters · 2016Article
- Current achievements of nanoparticle applications in developing optical sensing and imaging techniques.Nano convergence · 2016Review
- Localized Surface Plasmon Resonance Biosensing: Current Challenges and Approaches.Sensors (Basel, Switzerland) · 2015Review
- Au nanostructure arrays for plasmonic applications: annealed island films versus nanoimprint lithography.Nanoscale research letters · 2015Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Localized surface plasmon resonance (LSPR) spectroscopy has been widely used for label-free, highly sensitive measurements of interactions at a surface. LSPR imaging (LSPRi) has the full advantages of LSPR but enables high-throughput, multiplexed measurements by simultaneously probing multiple individually addressable sensors on a single sample surface. Each spatially distinct sensor can be tailored to provide data regarding different surface functionalities or reaction environments. Previously, LSPRi has focused on single-particle sensing where the size scale is very small. Here, we create defined macroscale arrays of nanoparticles that are compatible with common patterning methods such as dip-pen nanolithography and multichannel microfluidic delivery devices. With this new LSPR sensing format, we report the first demonstration of multiplexed LSPR imaging and show that the increased throughput of our instrument enables the collection of a complete Langmuir binding curve on a single sensor surface. In addition, the multiplexed LSPR sensor is highly selective, as demonstrated by the hybridization of single-stranded DNA to complementary sequences immobilized on the sensor surface. The LSPR arrays described in this work exhibit uniform sensitivity and tailorable optical properties, making them an ideal platform for high-throughput, label-free analysis of a variety of molecular binding interactions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.