ArticleBMC pediatrics2013
Prospective assessment of the gastroesophageal microbiome in VLBW neonates.
Article in BMC pediatrics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Potential NICU Environmental Influences on the Neonate's Microbiome: A Systematic Review.Advances in neonatal care : official journal of the National Association of Neonatal Nurses · 2015Pooled it
- Unveiling the gastric microbiota: implications for gastric carcinogenesis, immune responses, and clinical prospects.Journal of experimental & clinical cancer research : CR · 2024Review
- A comparison of bacterial colonization between nasogastric and orogastric enteral feeding tubes in infants in the neonatal intensive care unit.Journal of perinatology : official journal of the California Perinatal Association · 2022Article
- Neonatal Feeding Tube Colonization and the Potential Effect on Infant Health: A Review.Frontiers in nutrition · 2022Review
- Analysis of the Clinical Features of IntrauterineFrontiers in pediatrics · 2021Article
- [A review on the characteristics of microbiome and their association with diseases in preterm infants].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2020Review
- Bacterial colonization and antimicrobial resistance genes in neonatal enteral feeding tubes.FEMS microbiology ecology · 2019Article
- Microbiological monitoring of continuous positive airway pressure and resuscitation equipment in very-low birth weight infants.Pediatric research · 2018Article
- The Microbiota of the Extremely Preterm Infant.Clinics in perinatology · 2017Review
- Bacterial Diversity of the Gastric Content of Preterm Infants during Their First Month of Life at the Hospital.Frontiers in nutrition · 2017Article
- Nasogastric feeding tubes from a neonatal department yield high concentrations of potentially pathogenic bacteria- even 1 d after insertion.Pediatric research · 2016Observational
- The perinatal microbiome and pregnancy: moving beyond the vaginal microbiome.Cold Spring Harbor perspectives in medicine · 2015Review
- Trends and determinants of gastric bacterial colonization of preterm neonates in a NICU setting.PloS one · 2015Article
- Central line-associated bloodstream infections in neonates with gastrointestinal conditions: developing a candidate definition for mucosal barrier injury bloodstream infections.Infection control and hospital epidemiology · 2014Article
- The microbiome, parturition, and timing of birth: more questions than answers.Journal of reproductive immunology · 2014Review
- Participation of microbiota in the development of gastric cancer.World journal of gastroenterology · 2014Review
- A holobiont birth narrative: the epigenetic transmission of the human microbiome.Frontiers in genetics · 2014Article
- Ureaplasma species: role in neonatal morbidities and outcomes.Archives of disease in childhood. Fetal and neonatal edition · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe distal GI microbiota of hospitalized preterm neonates has been established to be unique from that of healthy full-term infants; the proximal GI, more specifically gastroesophageal colonization has not been systematically addressed. We prospectively evaluated early colonization of gastroesophageal portion of the GI tract of VLBW infants.
methodsThis study involved 12 infants admitted to a level III NICU with gestational age (GA) 27 +/- 0.5 weeks and birth weight 1105 +/- 77 grams. The gastroesophageal microbial flora was evaluated using 16S rDNA analysis of aspirates collected in a sterile manner during the first 28 days of life.
resultsBacteria were detected in 9 of the 12 neonates. Ureaplasma was the dominant species in the first week of life, however, staphylococci were the predominant bacteria overall. By the fourth week, Gram (-) bacteria increased in abundance to account for 50% of the total organisms. Firmicutes were present in the majority of the neonates and persisted throughout the 4 weeks comprising nearly half of the sequenced clones. Noticeably, only two distinct species of Staphylococcus epidermidis were found, suggesting acquisition from the environment.
conclusionsIn our neonates, the esophagus and stomach environment changed from being relatively sterile at birth to becoming colonized by a phylogenetically diverse microbiota of low individual complexity. By the fourth week, we found predominance of Firmicutes and Proteobacteria. Bacteria from both phyla (CONS and Gram (-) organisms) are strongly implicated as causes of hospital-acquired infections (HAI). Evaluation of the measures preventing colonization with potentially pathogenic and pathogenic microorganisms from the hospital environment may be warranted and may suggest novel approaches to improving quality in neonatal care.
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