Evidence map›Paper›PMID 23560297›Full record

Trial reportJAMA dermatology2013

Association of pediatric psoriasis severity with excess and central adiposity: an international cross-sectional study.

Amy S Paller, Katherine Mercy, Mary J Kwasny, Siew Eng Choon, Kelly M Cordoro, Giampiero Girolomoni, Alan Menter, Wynnis L Tom, Anne M Mahoney, Annet M Oostveen and 1 more

Registry-linked trialAbstract readClinical TrialMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in JAMA dermatology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00879944 (Impact of the Severity of Pediatric Psoriasis on Childhood Body Mass Index and Comorbid Risk Factors), which is not on this map. Cited by 44 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00879944 completednot on this map

Impact of the Severity of Pediatric Psoriasis on Childhood Body Mass Index and Comorbid Risk Factors: an Epidemiologic Analysis

TypeobservationalSponsorNorthwestern UniversityRan2009 to 2012Enrolled409ConditionsPsoriasis, Atopic DermatitisArmsBlood pressure, Height, Weight, BMI, Waist Circumference
3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Review
  14. Recommendations for Management of Childhood Psoriasis.Indian dermatology online journal · 2021
    Article
  15. Article
  16. Therapeutic challenges in managing pediatric psoriasis.International journal of women's dermatology · 2021
    Review
  17. Article
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Amy S PallerDepartment of Dermatology, Northwestern University, 676 N St Clair, Ste 1600, Chicago, IL 60611, USA. apaller@northwestern.edu
Katherine Mercy
Mary J Kwasny
Siew Eng Choon
Kelly M Cordoro
Giampiero Girolomoni
Alan Menter
Wynnis L Tom
Anne M Mahoney
Annet M Oostveen
Marieke M B Seyger

Funding

Genetic Influence in Pediatric PsoriasisK23AR060274 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI TOM, WYNNIS L · 2011 to 2015
$663k
NIAMS NIH HHS K23 AR060274
6 · The paper itself

Abstract

objectiveTo investigate the relationship of excess and central adiposity with pediatric psoriasis severity. DESIGN, SETTING, AND

participantsMulticenter, cross-sectional study of 409 psoriatic children. Psoriasis was classified as mild (worst Physician's Global Assessment score ≤3 with body surface area ≤10%) or severe (worst Physician's Global Assessment score ≥3 with body surface area >10%). Children were enrolled from 9 countries between June 19, 2009, and December 2, 2011.

main outcome measuresExcess adiposity (body mass index percentile) and central adiposity (waist circumference percentile and waist to height ratio).

resultsExcess adiposity (body mass index ≥85th percentile) occurred in 37.9% of psoriatic children (n=155) vs 20.5% of controls (n=42) but did not differ significantly by severity. The odds ratio (95% CI) of obesity (body mass index ≥95th percentile) overall in psoriatic children vs controls was 4.29 (1.96-9.39) and was higher with severe (4.92; 2.20-10.99) than with mild (3.60; 1.56-8.30) psoriasis, particularly in the United States (7.60; 2.47-23.34, and 4.72; 1.43-15.56, respectively). Waist circumference above the 90th percentile occurred in 9.3% of the control (n=19), 14.0% of the mild psoriasis (n=27), and 21.2% of the of severe psoriasis (n=43) participants internationally; this incidence was highest in the United States (12.0% [n=13], 20.8% [16], and 31.1% [32], respectively). Waist to height ratio was significantly higher in psoriatic (0.48) vs control (0.46) children but was unaffected by psoriasis severity. Children with severe psoriasis at its worst, but mild at enrollment, showed no significant difference in excess or central adiposity from children whose psoriasis remained severe.

conclusionsGlobally, children with psoriasis have excess adiposity and increased central adiposity regardless of psoriasis severity. The increased metabolic risks associated with excess and central adiposity warrant early monitoring and lifestyle modification.

trial registrationclinicaltrials.gov Identifier: NCT00879944

Indexed as

AdiposityAdolescentBody Mass IndexBody Surface AreaChildCross-Sectional StudiesFemaleHumansMalePsoriasisSeverity of Illness IndexUnited StatesWaist Circumference

Identifiers

PMID23560297
PMCPMC3624889

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.