ArticlePloS one2013
Diet-induced obesity promotes colon tumor development in azoxymethane-treated mice.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 43 citations in OpenAlex.
- A Review onEndocrine, metabolic & immune disorders drug targets · 2025Review
- Dysregulation of cellular membrane homeostasis as a crucial modulator of cancer risk.The FEBS journal · 2024Review
- Inflammasome signaling in colorectal cancer.Translational research : the journal of laboratory and clinical medicine · 2023Review
- Weight Loss and/or Sulindac Mitigate Obesity-associated Transcriptome, Microbiome, and Protumor Effects in a Murine Model of Colon Cancer.Cancer prevention research (Philadelphia, Pa.) · 2022Article
- Review
- ERβ and Inflammation.Advances in experimental medicine and biology · 2022Article
- Inflammatory Mediators and Gut Microbial Toxins Drive Colon Tumorigenesis by IL-23 Dependent Mechanism.Cancers · 2021Article
- NLRP3 inflammasome in cancer and metabolic diseases.Nature immunology · 2021Review
- The Role of Dyslipidemia in Colitis-Associated Colorectal Cancer.Journal of oncology · 2021Review
- High-fat diet and estrogen impacts the colon and its transcriptome in a sex-dependent manner.Scientific reports · 2020Article
- Effects of high-fat diet and intestinal aryl hydrocarbon receptor deletion on colon carcinogenesis.American journal of physiology. Gastrointestinal and liver physiology · 2020Article
- High-Fat Diet Propelled AOM/DSS-Induced Colitis-Associated Colon Cancer Alleviated by Administration ofBiology · 2020Article
- High Fat High Calories Diet (HFD) Increase Gut Susceptibility to Carcinogens by Altering the Gut Microbial Community.Journal of Cancer · 2020Article
- Occurrence of colorectal aberrant crypt foci depending on age and dietary patterns of patients.BMC cancer · 2018Article
- Transcriptome and DNA Methylome Analysis in a Mouse Model of Diet-Induced Obesity Predicts Increased Risk of Colorectal Cancer.Cell reports · 2018Article
- Preventive Effects of Pentoxifylline on the Development of Colonic Premalignant Lesions in Obese and Diabetic Mice.International journal of molecular sciences · 2017Article
- Weight loss following diet-induced obesity does not alter colon tumorigenesis in the AOM mouse model.American journal of physiology. Gastrointestinal and liver physiology · 2016Article
- Obesity promotes colonic stem cell expansion during cancer initiation.Cancer letters · 2015Article
- Inhibitory effects of astaxanthin on azoxymethane-induced colonic preneoplastic lesions in C57/BL/KsJ-db/db mice.BMC gastroenterology · 2014Article
- Thrombin drives tumorigenesis in colitis-associated colon cancer.Cancer research · 2014Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Obesity is an important risk factor for colon cancer in humans, and numerous studies have shown that a high fat diet enhances colon cancer development. As both increased adiposity and high fat diet can promote tumorigenesis, we examined the effect of diet-induced obesity, without ongoing high fat diet, on colon tumor development. C57BL/6J male mice were fed regular chow or high fat diet for 8 weeks. Diets were either maintained or switched resulting in four experimental groups: regular chow (R), high fat diet (H), regular chow switched to high fat diet (RH), and high fat diet switched to regular chow (HR). Mice were then administered azoxymethane to induce colon tumors. Tumor incidence and multiplicity were dramatically smaller in the R group relative to all groups that received high fat diet at any point. The effect of obesity on colon tumors could not be explained by differences in aberrant crypt foci number. Moreover, diet did not alter colonic expression of pro-inflammatory cytokines tumor necrosis factor-α, interleukin-6, interleukin-1β, and interferon-γ, which were measured immediately after azoxymethane treatment. Crypt apoptosis and proliferation, which were measured at the same time, were increased in the HR relative to all other groups. Our results suggest that factors associated with obesity - independently of ongoing high fat diet and obesity - promote tumor development because HR group animals had significantly more tumors than R group, and these mice were fed the same regular chow throughout the entire carcinogenic period. Moreover, there was no difference in the number of aberrant crypt foci between these groups, and thus the effect of obesity appears to be on subsequent stages of tumor development when early preneoplastic lesions transition into adenomas.
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