ArticlePloS one2013
Pre-diagnostic leukocyte genomic DNA methylation and the risk of colorectal cancer in women.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 22 citations in OpenAlex.
- Inhibitory immune checkpoints PDCD-1 and LAG-3 hypermethylation may reduce the risk of colorectal cancer.Molecular medicine (Cambridge, Mass.) · 2021Article
- A panel of DNA methylation signature from peripheral blood may predict colorectal cancer susceptibility.BMC cancer · 2020Article
- Impact of Global DNA Methylation in Treatment Outcome of Colorectal Cancer Patients.Frontiers in pharmacology · 2018Article
- LINE-1 methylation in peripheral blood leukocytes and clinical characteristics and prognosis of prostate cancer patients.Oncotarget · 2017Article
- Value ofArchives of medical science : AMS · 2017Article
- Multiple gene-specific DNA methylation in blood leukocytes and colorectal cancer risk: a case-control study in China.Oncotarget · 2017Article
- Acceleration of leukocytes' epigenetic age as an early tumor and sex-specific marker of breast and colorectal cancer.Oncotarget · 2017Article
- miR-148a and miR-375 may serve as predictive biomarkers for early diagnosis of laryngeal carcinoma.Oncology letters · 2016Article
- Constitutional epimutation as a mechanism for cancer causality and heritability?Nature reviews. Cancer · 2015Review
- Causes of genome instability: the effect of low dose chemical exposures in modern society.Carcinogenesis · 2015Review
- Global methylation levels in peripheral blood leukocyte DNA by LUMA and breast cancer: a case-control study in Japanese women.British journal of cancer · 2014Article
- Biomarkers measured in buccal and blood leukocyte DNA as proxies for colon tissue global methylation.International journal of molecular epidemiology and genetics · 2014Article
- Association between hypermethylation of DNA repetitive elements in white blood cell DNA and early-onset colorectal cancer.Epigenetics · 2013Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundAbnormal one-carbon metabolism may lead to general genomic (global) hypomethylation, which may predispose an individual to the development of colorectal neoplasia.
methodsWe evaluated the association between pre-diagnostic leukocyte genomic DNA methylation level and the risk of colorectal cancer in a nested case-control study of 358 colorectal cancer cases and 661 matched controls within the all-female cohort of the Nurses' Health Study (NHS). Among control subjects, we further examined major plasma components in the one-carbon metabolism pathway in relation to genomic DNA methylation level. Liquid chromatography/tandem mass spectrometry was used to examine leukocyte genomic DNA methylation level. We calculated odds ratios (ORs) and 95% confidence intervals (95% CIs) using logistic regression.
resultsOverall genomic DNA methylation level was not associated with the risk of colorectal cancer (p for trend, 0.45). Compared with women in the lowest quintile of methylation, the multivariate OR of colorectal cancer risk was 1.32 (95% CI, 0.82-2.13) for those in the highest quintile. We did not find significant associations between major plasma components of one-carbon metabolism or risk factors for colorectal cancer and genomic DNA methylation level (all p for trend >0.05). Also, neither one-carbon metabolism-related plasma components nor well-known risk factors for colorectal cancer modified the association between genomic DNA methylation level and the risk of colorectal cancer (all p for interaction >0.05).
conclusionsWe found no evidence that hypomethylation of leukocyte genomic DNA increases risk of colorectal cancer among women. Additional studies are needed to investigate the association between pre-diagnostic genomic DNA methylation level and colorectal cancer risk among diverse populations.
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