ArticleAsian journal of neurosurgery2012
Primary intracranial germ cell tumors.
Article in Asian journal of neurosurgery, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Basal Ganglia Germ Cell Tumors With or Without Sellar Involvement: A Long-Term Follow-Up in a Single Medical Center and a Systematic Literature Review.Frontiers in endocrinology · 2021Pooled it
- Identification and validation of liquid biopsy-based methylation biomarkers for germ cell tumor subtypes.Communications medicine · 2026Article
- Primary Intracranial Sarcomatoid Yolk Sac Tumor With Unique Histology: A Case Report.Case reports in pathology · 2025Article
- Germinoma of basal ganglia.Radiology case reports · 2024Article
- Plasma miRNA expression profile in pediatric pineal pure germinomas.Frontiers in oncology · 2024Article
- Mediastinal metastases from a primary immature teratoma of the CNS.Radiology case reports · 2022Article
- Multidisciplinary treatment of primary intracranial yolk sac tumor: A case report and literature review.Medicine · 2021Review
- Imaging of brain tumors in children: the basics-a narrative review.Translational pediatrics · 2021Review
- Yolk sac tumor of the fourth ventricle in a 3-year-old boy: imaging features.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2020Article
- A Case Report Emphasizing the Importance of Early Diagnosis and Management of Intracranial Germinoma.Cureus · 2020Article
- T2*-based MR imaging (gradient echo or susceptibility-weighted imaging) in midline and off-midline intracranial germ cell tumors: a pilot study.Neuroradiology · 2018Article
- Comparative genomic analysis of intracranial germ cell tumors - the preliminary study focused on Sonic Hedgehog signaling pathway.Contemporary oncology (Poznan, Poland) · 2017Article
- Intracranial multiple germ cell tumors: a case report and review of literature.International journal of clinical and experimental pathology · 2014Review
- Progressive hemiparesis in a young man: Hemicerebral atrophy as the initial manifestation of basal ganglia germinoma.Asian journal of neurosurgeryArticle
- Capsuloganglionic Germinoma: A Rare Site for Uncommon Childhood Tumor.Asian journal of neurosurgeryArticle
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPrimary intracranial germ cell tumors are rare (ICGCTs) and usually localized in the pineal and suprasellar regions of the brain. They are divided into histologic types: Germinoma, teratoma choriocarcinoma, embryonal carcinoma, yolk sac tumor, and malignant mixed germ cell tumors (MMGCTs). Neuroimaging evaluation is useful to distinguish between the types of ICGCTs. Germinoma is highly sensitive to radiotherapy or/and chemotherapy, and is potentially curable without surgery. MMGCTs are treated with the combination of chemotherapy and radiation, with a poorer prognosis. ICGCTs warrant correct pre-operative diagnosis in order to decide on appropriate management.
aimTo report the clinicopathological and immunohistochemical findings in three cases of primary intracranial germ-cell tumor. MATERIALS AND
methodsThree cases of intracranial germ cell tumors inclusive of both genders and all brain regions were retrieved from the archives of the Anatomical Pathology Department at King Abdul Aziz University Hospital, Jeddah between the years, 1995-2011, through a computerized search.
resultsBased on histological examination, they were respectively diagnosed as MMGCTs (two cases) and germinoma. Clinical, radiological, pathological characteristics and immunohistochemical profile of the three ICGCTs are presented along with the review of recent literature.
conclusionICGCTs are rare tumors affecting males more than females, and at the end of three years follow-up in the present study, treatment morbidity appears to be low with no recurrence observed among surviving patients, indicating that suprasellar and basal ganglia ICGCTs may have a favorable prognosis regardless of histological type. Pineal MMGCTs may have an aggressive course.
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