ArticleClinical journal of the American Society of Nephrology : CJASN2013
Candidate gene analysis of arteriovenous fistula failure in hemodialysis patients.
Article in Clinical journal of the American Society of Nephrology : CJASN, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Future research directions to improve fistula maturation and reduce access failure.Seminars in vascular surgery · 2016Review
- The molecular mechanisms of hemodialysis vascular access failure.Kidney international · 2016Review
- A Patient with Recurrent Arteriovenous Graft Thrombosis.Clinical journal of the American Society of Nephrology : CJASN · 2015Article
- Candidate Gene Analysis of Mortality in Dialysis Patients.PloS one · 2015Article
- Role of pharmacogenomics in dialysis and transplantation.Current opinion in nephrology and hypertension · 2014Article
- Novel paradigms for dialysis vascular access: downstream vascular biology--is there a final common pathway?Clinical journal of the American Society of Nephrology : CJASN · 2013Review
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Authors and funding
6 authors.
Funding
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Abstract
BACKGROUND AND
objectivesArteriovenous fistula (AVF) failure remains an important cause of morbidity in hemodialysis patients. The exact underlying mechanisms responsible for AVF failure are unknown but processes like proliferation, inflammation, vascular remodeling, and thrombosis are thought to be involved. The current objective was to investigate the association between AVF failure and single nucleotide polymorphisms (SNPs) in genes related to these pathophysiologic processes in a large population of incident hemodialysis patients. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: A total of 479 incident hemodialysis patients were included between January 1997 and April 2004. Follow-up lasted 2 years or until AVF failure, defined as surgery, percutaneous endovascular intervention, or abandonment of the vascular access. Forty-three SNPs in 26 genes, related to proliferation, inflammation, endothelial function, vascular remodeling, coagulation, and calcium/phosphate metabolism, were genotyped. Relations were analyzed using Cox regression analysis.
resultsIn total, 207 (43.2%) patients developed AVF failure. After adjustment, two SNPs were significantly associated with an increased risk of AVF failure. The hazard ratio (95% confidence interval) of LRP1 rs1466535 was 1.75 (1.15 to 2.66) and patients with factor V Leiden had a hazard ratio of 2.54 (1.41 to 4.56) to develop AVF failure. The other SNPs were not associated with AVF failure.
conclusionsIn this large cohort of hemodialysis patients, only 2 of the 43 candidate SNPs were associated with an increased risk of AVF failure. Whether other factors, like local hemodynamic circumstances, are more important or other SNPs play a role in AVF failure remains to be elucidated.
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