Observational studyClinical journal of the American Society of Nephrology : CJASN2013
Vascular and renal hemodynamic changes after renal denervation.
Observational study in Clinical journal of the American Society of Nephrology : CJASN, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.
- Arterial spin labelling MRI to measure renal perfusion: a systematic review and statement paper.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2018Pooled it
- Abdominal Aortic Calcifications Influences the Systemic and Renal Hemodynamic Response to Renal Denervation in the DENERHTN (Renal Denervation for Hypertension) Trial.Journal of the American Heart Association · 2017Trial
- Assessment of renal allograft cortical perfusion in the early postoperative period using arterial spin labeling magnetic resonance imaging.Quantitative imaging in medicine and surgery · 2026Article
- Insight into Kidney Function and Microstructure Through Renal MRI-Review of the Literature.Bioengineering (Basel, Switzerland) · 2026Review
- Autonomic control of the vasculature in CKD: leveraging renal denervation.Frontiers in neuroscience · 2026Review
- Increased plasma levels of erythropoietin after renal denervation in patients with resistant hypertension.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Article
- The effect of renal denervation in microcirculation: focusing on coronary microvascular dysfunction.Future cardiology · 2025Review
- Comparison of the effects of renal denervation at early or advanced stages of hypertension on cardiac, renal, and adipose tissue pathology in Dahl salt-sensitive rats.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Article
- Renal Glucose Release after Unilateral Renal Denervation during a Hypoglycemic Clamp in Pigs with an Altered Hypothalamic Pituitary Adrenal Axis after Late-Gestational Dexamethasone Injection.International journal of molecular sciences · 2023Article
- A new use of transcutaneous electrical nerve stimulation: Role of bioelectric technology in resistant hypertension (Review).Biomedical reports · 2023Review
- ADAM10 and ADAM17, Major Regulators of Chronic Kidney Disease Induced Atherosclerosis?International journal of molecular sciences · 2023Review
- The denervation or activation of renal sympathetic nerve and renal blood flow.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2023Review
- Pressure-Natriuresis Response Is Diminished in Old Age.Frontiers in cardiovascular medicine · 2022Article
- Effects of renal denervation on kidney function and long-term outcomes: 3-year follow-up from the Global SYMPLICITY Registry.European heart journal · 2019Article
- Device-Based Neuromodulation for Resistant Hypertension Therapy.Circulation research · 2019Review
- Mechanisms of altered renal sodium handling in age-related hypertension.American journal of physiology. Renal physiology · 2018Review
- Non-Invasive Renal Perfusion Imaging Using Arterial Spin Labeling MRI: Challenges and Opportunities.Diagnostics (Basel, Switzerland) · 2018Review
- Blood Pressure and Renal Responses to Orthostatic Stress Before and After Radiofrequency Renal Denervation in Patients with Resistant Hypertension.Frontiers in cardiovascular medicine · 2018Article
- Renal sympathetic denervation increases renal blood volume per cardiac cycle: a serial magnetic resonance imaging study in resistant hypertension.International journal of nephrology and renovascular disease · 2017Article
- Renal sympathetic denervation in therapy resistant hypertension - pathophysiological aspects and predictors for treatment success.World journal of cardiology · 2016Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesRenal denervation (RDN) has been shown to be effective in reducing BP in treatment-resistant hypertension. Measurement of the renal and sympathetic activity revealed a decrease in sympathetic drive to the kidney and small resistance vessels after RDN. However, the consequences on renal perfusion and renal vascular resistance (RVR), as well as central hemodynamics, are unknown. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Nineteen patients with treatment-resistant hypertension (office BP≥140/90 mmHg, despite at least three antihypertensive drugs [including a diuretic], and diagnosis confirmed by 24-hour ambulatory BP monitoring) underwent RDN between January and October 2011. Renal perfusion and RVR were noninvasively assessed by magnetic resonance imaging with arterial spin labeling, and renal function was assessed by estimating GFR before (day -1), after (day +1), and again after 3 months of RDN. Central hemodynamics was assessed using pulse wave analysis at day -1 and after 6 months of RDN.
resultsPeripheral office BP (systolic, 158±26 versus 142±23 mmHg, P=0.002; diastolic, 83±13 versus 76±9 mmHg, P=0.02) and mean systolic 24-hour ambulatory BP (159±17 versus 152±17 mmHg, P=0.02) were significantly reduced 6 months after RDN. Renal perfusion was not statistically different between day -1 and day +1 (256.8 [interquartile range (IQR), 241-278] versus 263.4 [IQR, 252-277] ml/min per 100 g; P=0.17) as well as after 3 months (256.8 [IQR, 241-278] versus 261.2 [IQR, 240-285] ml/min per 100 g; P=0.27) after RDN. RVR dropped (432.1 [IQR, 359-525] versus 390.6 [IQR, 338-461] AU; P=0.02), whereas renal function was not statistically different at any time point. Central systolic BP (145±31 versus 131±28 mmHg; P=0.009), diastolic BP (85±18 versus 80±14 mmHg; P=0.03), and central pulse pressure (61±18 versus 52±18 mmHg; P=0.02) were significantly reduced 6 months after RDN. Central augmentation index (24±8 versus 20±8%; P=0.02) was decreased 6 months after RDN.
conclusionThe data indicate that RDN significantly reduced peripheral and central BP. Despite reduced systemic BP, renal perfusion and function did not change after RDN.
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