ArticlePhysical therapy2013
Alzheimer disease alters the relationship of cardiorespiratory fitness with brain activity during the stroop task.
Article in Physical therapy, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 23 citations in OpenAlex.
- [Effect of physical exercise on Alzheimer's disease. A sistematic review].Atencion primaria · 2020Pooled it
- Cerebral changes improved by physical activity during cognitive decline: A systematic review on MRI studies.NeuroImage. Clinical · 2019Pooled it
- LEAP! Rx: A randomized trial of a pragmatic approach to lifestyle medicine.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Trial
- Alzheimer's Disease: Understanding Motor Impairments.Brain sciences · 2024Review
- Impact of physical exercise on the regulation of brain-derived neurotrophic factor in people with neurodegenerative diseases.Frontiers in neurology · 2024Review
- Establishing Reference Cardiorespiratory Fitness Parameters in Alzheimer's Disease.Sports medicine international open · 2020Article
- Interaction between physical exercise and APOE gene polymorphism on cognitive function in older people.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2020Review
- An Overview of the Cardiorespiratory Hypothesis and Its Potential Contribution to the Care of Neurodegenerative Disease in Africa.Medicina (Kaunas, Lithuania) · 2019Review
- Effects of Cardiorespiratory Exercise on Cognition in Older Women Exposed to Air Pollution.International journal of environmental research and public health · 2019Article
- Determination of Aerobic Capacity via Cycle Ergometer Exercise Testing in Alzheimer's Disease.American journal of Alzheimer's disease and other dementias · 2017Article
- Decreased tidal volume may limit cardiopulmonary performance during exercise in subacute stroke.Journal of cardiopulmonary rehabilitation and preventionArticle
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundDespite mounting evidence that physical activity has positive benefits for brain and cognitive health, there has been little characterization of the relationship between cardiorespiratory (CR) fitness and cognition-associated brain activity as measured by functional magnetic resonance imaging (fMRI). The lack of evidence is particularly glaring for diseases such as Alzheimer disease (AD) that degrade cognitive and functional performance.
objectiveThe aim of this study was to describe the relationship between regional brain activity during cognitive tasks and CR fitness level in people with and without AD.
designA case-control, single-observation study design was used.
methodsThirty-four individuals (18 without dementia and 16 in the earliest stages of AD) completed maximal exercise testing and performed a Stroop task during fMRI.
resultsCardiorespiratory fitness was inversely associated with anterior cingulate activity in the participants without dementia (r=-.48, P=.05) and unassociated with activation in those with AD (P>.7). Weak associations of CR fitness and middle frontal cortex were noted. LIMITATIONS: The wide age range and the use of a single task in fMRI rather than multiple tasks challenging different cognitive capacities were limitations of the study.
conclusionsThe results offer further support of the relationship between CR fitness and regional brain activity. However, this relationship may be attenuated by disease. Future work in this area may provide clinicians and researchers with interpretable and dependable regional fMRI biomarker signatures responsive to exercise intervention. It also may shed light on mechanisms by which exercise can support cognitive function.
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Registered trials
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